Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2014010062
pages 103-120

Regulation of Chemokine Expression in the Tumor Microenvironment

Anton V. Gorbachev
Department of Immunology, Cleveland Clinic, Cleveland, OH, 44195
Robert L. Fairchild
Department of Immunology and Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195 and Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106

Краткое описание

Chemokines are chemotactic cytokines critical for homeostatic and inflammation-induced trafficking of leukocytes during immune responses, hematopoesis, wound healing, and tumorigenesis. Despite three decades of intensive study of the chemokine network, the molecular mechanisms regulating chemokine expression during tumor growth are not well understood. In this review, we focus on the role of chemokines in both tumor growth and anti-tumor immune responses and on molecular mechanisms employed by tumor cells to regulate chemokine expression in the tumor microenvironment. Multiple mechanisms used by tumors to regulate chemokine production, including those revealed by very recent studies (such as DNA methylation or post-translational nitrosylation of chemokines) are discussed. Concluding the review, we discuss how understanding of these regulatory mechanisms can be used in cancer therapy to suppress tumor growth and/or to promote immune-mediated eradication of tumors.

Ключевые слова: chemokines, tumorigenesis, cancer therapy

Articles with similar content:

The Pathophysiological Role of Chemokines in the Regulation of NK Cell Tissue Homing
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 1-2
Giovanni Bernardini, Angela Santoni
Tumor-Stromal Interactions in Pancreatic Cancer
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 1 - 2
Daniel D. Von Hoff, Richard G. Posner, Haiyong Han, Clifford Whatcott
NPR-A: A Therapeutic Target in Inflammation and Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 1
Jia Zhang, Junhai Li, Yan Yan, Jiansheng Wang, Ya Yang, Jingkun Qu, Min Li
The Ron Receptor Tyrosine Kinase: A Key Regulator of Inflammation and Cancer Progression
Critical Reviews™ in Immunology, Vol.33, 2013, issue 6
Pamela A. Hankey, Xin Wang
Regulatory Roles of the Tumor Necrosis Factor Receptor BCMA
Critical Reviews™ in Immunology, Vol.32, 2012, issue 4
Loren D. Erickson, Christine M. Coquery