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Critical Reviews™ in Immunology
Импакт фактор: 1.404 5-летний Импакт фактор: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 40, 2020 Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v20.i1.40
4 pages

Chronic Allograft Rejection Associated Vasculopathy and Synthetic Biodegradable Vascular Grafts: A Lesson to Learn?

Paul Nieuwenhuis
Department of Histology and Cell Biology, Faculty of Medical Sciences, University of Groningen, Oostersingel 69-1, 9713 EZ Groningen, the Netherlands
Jan-Luuk Hillebrands
Department of Histology and Cell Biology, Faculty of Medical Sciences, University of Groningen, Oostersingel 69-1, 9713 EZ Groningen, the Netherlands
Jan Rozing
Department of Histology and Cell Biology, Faculty of Medical Sciences, University of Groningen, Oostersingel 69-1, 9713 EZ Groningen, the Netherlands

Краткое описание

In chronic allograffs, graft vessels eventually develop so-called "transplant vascular sclerosis" or "intimal hyperplasia". A major question is whether the cells in the neointima are donor or recipient derived. The process of transplant vascular sclerosis closely resembles the remodeling of the vascular wall as seen when synthetic biodegradable small caliber vascular grafts are implanted. In this model, the cells in the newly developing neointima as well as neomedia are, by definition, recipient derived.
By using cardiac allografts as well as aortic allografts exchanged between a female donor and a male recipient (rats), the origin of the neointimal vascular smooth muscle cells could be traced by looking for the Y-chromosome in isolated (α-actin positive) intimal cells using PCR. In both models these intimal cells were found to be of recipient-origin.
It is proposed, that, basically, this remodeling process is part of a normal healing process. Whereas in biodegradable grafts this "healing process" appears to be self limiting, in allografts the process goes on beyond the needs of functional repair, eventually, in some cases, leading to total vascular occlusion. Future therapeutic protocols might try and aim at controlling this essentially normal repair process.


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