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Critical Reviews™ in Immunology
Импакт фактор: 1.352 5-летний Импакт фактор: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472

Выпуски:
Том 39, 2019 Том 38, 2018 Том 37, 2017 Том 36, 2016 Том 35, 2015 Том 34, 2014 Том 33, 2013 Том 32, 2012 Том 31, 2011 Том 30, 2010 Том 29, 2009 Том 28, 2008 Том 27, 2007 Том 26, 2006 Том 25, 2005 Том 24, 2004 Том 23, 2003 Том 22, 2002 Том 21, 2001 Том 20, 2000 Том 19, 1999 Том 18, 1998 Том 17, 1997 Том 16, 1996 Том 15, 1995 Том 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v30.i6.20
pages 515-527

Modulation of Innate Immune Responses by Hantaviruses

Andreas Rang
Institute of Medical Virology, University Hospital, Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, D-10098, Germany

Краткое описание

Hantavirus infection can cause hantavirus cardiopulmonary syndrome or hemorrhagic fever with renal syndrome depending on the virus species involved. The determinants for the virus species specific virulence in humans are unclear. Successful infection is a conditio sine qua non for the virulence of a virus and it is well-known that the innate interferon (IFN) system generally plays a decisive role to prevent establishment of an infection. The importance of the IFN system is underscored by the fact that viruses have developed an amazing number of different escape mechanisms to enable replication in face of the antiviral host response. Interestingly, pathogenic hantaviruses escape induction of innate antiviral responses in the early phase of the infection, which are elicited in a pronounced manner by nonpathogenic hantaviruses in vitro. This differential response might be important for the pathogenicity of hantaviruses in humans. This review aims to summarize the current knowledge about the interaction between hantaviruses and the innate IFN system. Detailed characterization of the cellular sensors and pathways that lead to activation of the IFN system on one side and the viral escape mechanisms on the other might help to develop novel vaccination strategies and therapeutic approaches.

Ключевые слова: TRAF3, TLR3, interferon-lambda, antiviral state, reassortment

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