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ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X
Indexed in
Therapeutic Uses of Drug-Carrier Systems for Imidazole-Containing Dipeptide Compounds That Act as Pharmacological Chaperones and Have Significant Impact on the Treatment of Chronic Diseases Associated With Increased Oxidative Stress and the Formation of Advanced Glycation End Products
Краткое описание
The purpose of this study was to determine how the naturally occurring molecules N-acetylcarnosine, L-carnosine, and carcinine, which are chemical or pharmacological chaperones, affect the cells and biomolecules of patients with skin diseases, cosmetic skin lesions, or underlying clinically significant visual impairment such as age-related cataracts, age-related retinal degeneration, and ocular complications of diabetes. We evaluated and characterized the effects of cited pharmacological chaperones on enzyme activity, protein structure in tissues, and other biomarkers of diseases in skin cells and tissues or in ocular tissues (human cataractous and normal lenses) derived from ophthalmic patients or age-matched donors. The samples were used to test imidazolecontaining peptidomimetic chemical/pharmacological chaperones in relation to oxidative stress induced by reaction with lipid peroxides or advanced non-enzymatic glycation processes. Chaperone function is characterized by interaction with other proteins, mediating their folding, transport, and interaction with other molecules, lipid peroxidation products, and membranes. Although these therapies remain on hold pending further investigation, we present growing evidence demonstrating the ability of N-acetylcarnosine (lubricant eye drops) or carcinine pharmacological chaperone therapy to act as novel treatments for age-related cataracts, age-related macular degeneration, and ocular complications of diabetes. Finally, we examine strategies for identifying potential chaperone compounds and for experimentally demonstrating chaperone and transglycating (de-glycation) types of activity in in vitro and in vivo models of human age-related eye diseases, such as cataracts, and advanced glycation tissue protein-engineered systems.
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Babizhayev Mark A., Strokov Igor A., Nosikov Valery V., Savel’yeva Ekaterina L., Sitnikov Vladimir F., Yegor E. Yegorov , Lankin Vadim Z., The Role of Oxidative Stress in Diabetic Neuropathy: Generation of Free Radical Species in the Glycation Reaction and Gene Polymorphisms Encoding Antioxidant Enzymes to Genetic Susceptibility to Diabetic Neuropathy in Population of Type I Diabetic Patients, Cell Biochemistry and Biophysics, 71, 3, 2015. Crossref
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Gragnani Alfredo, Cornick Sarita Mac, Chominski Verônica, Ribeiro de Noronha Samuel Marcos, Alves Corrêa de Noronha Silvana Aparecida, Ferreira Lydia Masako, Review of Major Theories of Skin Aging, Advances in Aging Research, 03, 04, 2014. Crossref
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Kyriazis Marios, Anti-ageing potential of carnosine: approaches toward successful ageing, Drug Discovery Today: Therapeutic Strategies, 7, 3-4, 2010. Crossref
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Wu Chi-Hao, Huang Shang-Ming, Lin Jer-An, Yen Gow-Chin, Inhibition of advanced glycation endproduct formation by foodstuffs, Food & Function, 2, 5, 2011. Crossref
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Caruso Giuseppe, Caraci Filippo, Jolivet Renaud B., Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders, Progress in Neurobiology, 175, 2019. Crossref
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Steiner Denise, Marçon Carolina Reato, Sabban Emilia Noemí Cohen, Diabetes, Non-Enzymatic Glycation, and Aging, in Dermatology and Diabetes, 2018. Crossref
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Babizhayev Mark A., Vishnyakova Khava S., Yegorov Yegor E., Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting, Journal of Basic and Clinical Physiology and Pharmacology, 26, 2, 2015. Crossref
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Ergin Volkan, Bali Elif Burcu, Hariry Reza Ebrahimi, Karasu Çimen, Natural products and the aging process, Hormone Molecular Biology and Clinical Investigation, 16, 2, 2013. Crossref
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Zhao Man, Song Xiangting, Liu Wei, Qi Fengjie, Zhao Tingting, Xia Keke, Liu Zhiqiang, Zheng Yuguo, Whole-cell biotransformation for large scale production of carcinine in Escherichia coli, Journal of Biotechnology, 354, 2022. Crossref
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Babizhayev Mark A., Deyev Anatoliy I., Savel'Yeva Ekaterina L., Lankin Vadim Z., Yegorov Yegor E., Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging, Journal of Dermatological Treatment, 23, 5, 2012. Crossref