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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Therapeutic Drug Carrier Systems

Импакт фактор: 5.367

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2017016983
pages 35-61

Applications and Risks of Nanomaterials Used in Regenerative Medicine, Delivery Systems, Theranostics, and Therapy

Estefany I. Medina-Reyes
Laboratorio 10, Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de México, CP 54090, Estado de México, México; Programa de Posgrado en Ciencias Biomédicas, Universidad Nacional Autonoma de México
Danae Garcia-Viacobo
Laboratorio 10, Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de México, CP 54090, Estado de México, México
Franklin A. Carrero- Martinez
Department of Anatomy and Neuroscience, School of Medicine, University of Puerto Rico, P.O. Box 365067, San Juan, PR 00936-5067
Yolanda Irasema Chirino
Laboratorio 10, Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de México, CP 54090, Estado de México, México

Краткое описание

Recent advances in nanotechnology have transformed the biomedicine field, in which the use of engineered nanomaterials (ENMs) has provided the foundation for novel applications. For this reason, the number of ENMs has increased rapidly, and here we provide a classification of ENMs based on chemical composition and biomedical applications, which include regenerative medicine, delivery systems, theranostics, and therapy. These have been identified as the most advanced and promising areas for further studies with humans. In addition, we discuss possible side effects related to ENM uses. We identify carbon, metal, and metal oxides as the most versatile ENM material groups, used in bone and neuronal regenerative medicine, thermal therapy, theranostics, drug delivery, gene therapy, and biosensors. However, the majority of drugs approved by the U.S. Food and Drug Administration (FDA) are lipid-based ENMs. We conclude that biomedical applications of ENMs offer potential benefits while side effects are mainly associated with occupational exposure. Finally, we suggest that in the future, nanocomposites, subnanometric structures, and biodegradable and biocorona formation could be used to improve the biomedical field by focusing on infectious diseases, early detection, and precision medicine.