Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 36, 2019 Том 35, 2018 Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v14.i1.10
104 pages

Cyclodextrins—Enabling Excipients: Their Present and Future Use in Pharmaceuticals

Diane O. Thompson
CyDex, L. C, 7304 West 130th Street, Suite 370, Overland Park, KS 66213-2627

Краткое описание

Cyclodextrins (CDs) complex hydrophobic drugs, increasing their aqueous solubility and stability. CD coraplexation enables the creation of formulations for water-insoluble drugs that are difficult to deliver with more traditional formulations. Currently, 10 pharmaceutical products are marketed as CD formulations. A CD-based formulation, like any other, is evaluated for quality and safety. The 6 CDs currently available for use in pharmaceutical products are α-, β-, and γ-CD and the methyl (M), hydroxypropyl (HP), and sulfobutylether (SBE) derivatives of β-CD. The structural features of these CDs are evaluated for their affect on complexation performance. Optimal specifications, quality production, and safety of each CD is presented. The current and future regulatory process facing excipients is summarized, and the current regulatory status of the CDs in Japan, the United States, and Europe is presented.


Articles with similar content:

Effect of Ions of Lead and Ammonium on Bioproduction Parameters of Young Fishes
Hydrobiological Journal, Vol.35, 1999, issue 5
V. P. Gandzyura, A. A. Ignatyuk
Global Marketing of Medicinal Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Products and Safety Concerns
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 2
Yihuai Gao, Shufeng Zhou, Tim Lai
Fractional Distribution of Heavy Metals in Bottom Sediments of the Dnieper Reservoirs
Hydrobiological Journal, Vol.35, 1999, issue 2
I. B. Zubenko, P. N. Linnik
Medicinal Value of Turkey Tail Fungus Trametes versicolor (L.:Fr.) Pilát (Aphyllophoromycetideae). A Literature Review
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 3
Christopher Hobbs
Medicinal Mushroom Science: History, Current Status, Future Trends, and Unsolved Problems
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 1
Solomon P. Wasser