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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Therapeutic Drug Carrier Systems

Импакт фактор: 5.367

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2016015798
pages 309-361

Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems

Swarna Bale
Laboratory of Nano-Biology, Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, India
Amit Khurana
Laboratory of Nano-Biology, Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, India
A. Shiva Shankar Reddy
Laboratory of Nano-Biology, Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, India
Mandip Singh
College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida
Chandraiah Godugu
Laboratory of Nano-Biology, Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, Telangana, India

Краткое описание

Research in novel drug delivery systems is being explored competitively in order to attain maximum therapeutic effect while minimizing the adverse effects. Despite several advancements in pharmaceutical formulations, one of the major challenges still persisting is sustained drug release. Microencapsulation enacts as an intelligent approach with a strong therapeutic impact and is in demand globally in medical technology due to its specific and attractive properties, including biocompatibility, stability, target specificity, uniform encapsulation, better compliance, and controlled and sustained release patterns that are responsible for diminishing the toxicity and dosage frequency. Microparticles are successful delivery systems that encapsulate both water-insoluble and sparingly water-soluble agents to elicit their efficacy with a great potential attributed to their unique properties: particle size, shape, structure, drug loading, entrapment efficiency, porosity, and release profile. Several marketed microparticle-based formulations are available, including risperidone, buserelin, and octreotide acetate, and some of them are in clinical trials. The present review highlights the detailed therapeutic applications of microparticles with advances from the last decade to treat various disease conditions, including cancer, diabetes, cardiovascular diseases, and neurological disorders, as well as for vaccine delivery, ocular and pulmonary delivery, gene transfer, etc., and exemplifies the future perspectives in these aspects. One day in the future, microparticle-based formulations may become broadly researched in drug delivery systems.