Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 36, 2019 Том 35, 2018 Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v29.i4.10
pages 265-298

Transcending the Skin Barrier to Deliver Peptides and Proteins Using Active Technologies

Neha Singh
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
Haripriya Kalluri
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
Anushree Herwadkar
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
Advait Badkar
Biotherapeutics Pharmaceutical R&D, Pfizer Inc., 700 Chesterfield Parkway (W), Chesterfield, Missouri 63017, USA
Ajay K. Banga
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, USA

Краткое описание

Peptides and proteins have been investigated as promising therapeutic agents over the past decade. These macromolecules are conventionally administered by the parenteral route because oral delivery is associated with degradation in the gastrointestinal tract. Transdermal delivery presents a promising alternative route of drug delivery, avoiding pain associated with parenteral administration and degradation issues associated with oral delivery. However, the barrier properties of skin limit delivery to only small, moderately lipophilic molecules. Hence, hydrophilic macromolecules like peptides and proteins cannot passively permeate across skin. Active physical enhancement approaches such as iontophoresis electroporation, microneedles treatment, and sonophoresis have been developed to assist transdermal delivery of peptides and proteins. This review describes active physical transdermal enhancement approaches for transdermal delivery of peptides and proteins. The mechanisms associated with each technique and important parameters governing transdermal delivery of peptides and proteins are discussed in detail. Combinations of enhancement techniques for synergistic enhancement in protein and peptide delivery are also discussed.


Articles with similar content:

Enhancement of Transdermal Delivery of Heparin by Various Physical and Chemical Enhancement Techniques
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 6
S. S. Lanke, Ajay K. Banga, J. G. Strom
Recent Developments in the Use of Bioadhesive Systems for Delivery of Drugs to the Oral Cavity
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 4
John D. Smart
PLGA Nanoparticles in Drug Delivery: The State of the Art
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 5
Sarita Hariharan, Indu Bala, M. N. V. Ravi Kumar
Functional Polymeric Nanoparticles: An Efficient and Promising Tool for Active Delivery of Bioactives
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.23, 2006, issue 4
Senthilkumar Murugesan, Tathagata Dutta, Abhay Asthana, Manoj Tare, Surbhi Saraf, Narendra Kumar Jain, Vijayaraj Rajkumar, Manoj Nahar, Dinesh Mishra
Cracking the Junction: Update on the Progress of Gastrointestinal Absorption Enhancement in the Delivery of Poorly Absorbed Drugs
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 2
David J. Brayden, Siobhan McClean, Sam Maher, Linda Feighery