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ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X
Indexed in
Sublingual Drug Delivery
Краткое описание
The sublingual route is one of the early modes of administration for systemic drug delivery. This route avoids first-pass metabolism and affords quick drug entry into the systemic circulation. Attempts have been made to deliver various pharmacologically active agents, such as cardiovascular drugs, analgesics, and peptides, across the sublingual mucosa. In this review, the anatomical structure, blood supply, biochemical composition, transport pathways, permeation enhancement strategies, in vitro / in vivo models, and clinical investigations for the sublingual route of drug delivery is discussed.
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Goswami Tarun, Kokate Amit, Jasti Bhaskara R., Li Xiaoling, In silico model of drug permeability across sublingual mucosa, Archives of Oral Biology, 58, 5, 2013. Crossref
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Wong Yin Cheong, Qian Shuai, Zuo Zhong, Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions, Expert Opinion on Drug Metabolism & Toxicology, 8, 7, 2012. Crossref
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Turunen Elina, Korhonen Ossi, Lehto Vesa-Pekka, Kauppinen Ari, Ahtiainen Hanne, Järvinen Kristiina, Jarho Pekka, Effect of storage on the dissolution rate of a fast-dissolving perphenazine/β-cyclodextrin complex, Journal of Pharmacy and Pharmacology, 66, 3, 2014. Crossref
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Bayrak Ziya, Tas Cetin, Tasdemir Umut, Erol Halil, Ozkan Cansel Kose, Savaser Ayhan, Ozkan Yalcin, Formulation of zolmitriptan sublingual tablets prepared by direct compression with different polymers: In vitro and in vivo evaluation, European Journal of Pharmaceutics and Biopharmaceutics, 78, 3, 2011. Crossref
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Bouchal F., Skiba M., Chaffai N., Hallouard F., Fatmi S., Lahiani-Skiba M., Fast dissolving cyclodextrin complex of piroxicam in solid dispersion Part I: Influence of β-CD and HPβ-CD on the dissolution rate of piroxicam, International Journal of Pharmaceutics, 478, 2, 2015. Crossref
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Turunen Elina, Mannila Janne, Laitinen Riikka, Riikonen Joakim, Lehto Vesa-Pekka, Järvinen Tomi, Ketolainen Jarkko, Järvinen Kristiina, Jarho Pekka, Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits, Journal of Pharmacy and Pharmacology, 63, 1, 2010. Crossref
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Ko Jeff C., Freeman Lynetta J., Barletta Michele, Weil Ann B., Payton Mark E., Johnson Brenda M., Inoue Tomohito, Efficacy of oral transmucosal and intravenous administration of buprenorphine before surgery for postoperative analgesia in dogs undergoing ovariohysterectomy, Journal of the American Veterinary Medical Association, 238, 3, 2011. Crossref
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Pinto João F., Site-specific drug delivery systems within the gastro-intestinal tract: From the mouth to the colon, International Journal of Pharmaceutics, 395, 1-2, 2010. Crossref
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Domm William, Brooks Lauren, Chung Hung Li, Feng Changyong, Bowers William J., Watson Gene, McGrath James L., Dewhurst Stephen, Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: Association with mucoadhesion and efficient penetration of the sublingual barrier, Vaccine, 29, 40, 2011. Crossref
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Bochot Amélie, Chambin Odile, Pillon François, Les voies transmuqueuses, des alternatives intéressantes, Actualités Pharmaceutiques, 50, 508, 2011. Crossref
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Bitner Daniel P., Uzbelger Feldman Daniel, Axx Kevin, Albandar Jasim M., Description and evaluation of an intraoral cervical plexus anesthetic technique, Clinical Anatomy, 28, 5, 2015. Crossref
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Morales Javier Octavio, Drug Delivery Systems: Oral Mucosal, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2015. Crossref
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Goswami Tarun, Jasti Bhaskara R., Li Xiaoling, Estimation of the theoretical pore sizes of the porcine oral mucosa for permeation of hydrophilic permeants, Archives of Oral Biology, 54, 6, 2009. Crossref
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Sivaraman Arunprasad, Banga Ajay K, Formulation and evaluation of sublingual delivery of piroxicam using thermosensitive polymer with an inverted Franz diffusion cell, Journal of Pharmacy and Pharmacology, 68, 1, 2016. Crossref
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Goswami Tarun, Li Xiaoling, Jasti Bhaskara R., Effect of Lipophilicity and Drug Ionization on Permeation Across Porcine Sublingual Mucosa, AAPS PharmSciTech, 18, 1, 2017. Crossref
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Sheu Ming-Thau, Hsieh Chien-Ming, Chen Ray-Neng, Chou Po-Yu, Ho Hsiu-O, Rapid-Onset Sildenafil Sublingual Drug Delivery Systems: In Vitro Evaluation and In Vivo Pharmacokinetic Studies in Rabbits, Journal of Pharmaceutical Sciences, 105, 9, 2016. Crossref
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Singh Harmanpreet, Narang Jasjeet Kaur, Singla Yash Paul, Narang Ramandeep Singh, Mishra Vijay, TPGS stabilized sublingual films of frovatriptan for the management of menstrual migraine: Formulation, design and antioxidant activity, Journal of Drug Delivery Science and Technology, 41, 2017. Crossref
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Solari S., Cancino A., Wolff R., Norero B., Vargas J. I., Barrera F., Guerra J. F., Martínez J., Jarufe N., Soza A., Arrese M., Benitez C., Sublingual tacrolimus administration provides similar drug exposure to per-oral route employing lower doses in liver transplantation: a pilot study, Alimentary Pharmacology & Therapeutics, 45, 9, 2017. Crossref
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Baltzley Sarah, Malkawi Azzam A., Alsmadi Motasem, Al-Ghananeem Abeer M., Sublingual spray drug delivery of ketorolac-loaded chitosan nanoparticles, Drug Development and Industrial Pharmacy, 44, 9, 2018. Crossref
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López-Cebral Rita, Peng Guangjia, Reys Lara L., Silva Simone S., Oliveira Joaquim M., Chen Jie, Silva Tiago H., Reis Rui L., Dual delivery of hydrophilic and hydrophobic drugs from chitosan/diatomaceous earth composite membranes, Journal of Materials Science: Materials in Medicine, 29, 2, 2018. Crossref
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dos Santos Chaves Paula, Visioli Fernanda, Buffon Andréia, Raffin Pohlmann Adriana, Stanisçuaski Guterres Sílvia, Beck Ruy Carlos Ruver, SCC4 cell monolayers as an alternative sublingual barrier model: influence of nanoencapsulation on carvedilol transport, Drug Development and Industrial Pharmacy, 45, 1, 2019. Crossref
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Chaves Paula Dos Santos, Frank Luiza Abrahão, Frank Alejandro Germán, Pohlmann Adriana Raffin, Guterres Sílvia Stanisçuaski, Beck Ruy Carlos Ruver, Mucoadhesive Properties of Eudragit®RS100, Eudragit®S100, and Poly(ε-caprolactone) Nanocapsules: Influence of the Vehicle and the Mucosal Surface, AAPS PharmSciTech, 19, 4, 2018. Crossref
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Chokshi Ashish, Vangara Kiran, Chilampalli Shivani, Narayanan Eshwaran, Potta Thrimoorthy, Development of sublingual spray formulation containing ondansetron hydrochloride dihydrate, Journal of Drug Delivery Science and Technology, 53, 2019. Crossref
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dos Santos Chaves Paula, Frank Luiza Abrahão, Torge Afra, Schneider Marc, Pohlmann Adriana Raffin, Guterres Sílvia Stanisçuaski, Beck Ruy Carlos Ruver, Spray-dried carvedilol-loaded nanocapsules for sublingual administration: Mucoadhesive properties and drug permeability, Powder Technology, 354, 2019. Crossref
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Leal‐Júnior Carlos C., Amorim Melania M.R., Souza Gustavo F.A., Lima Anna K.S., Souza Alex S.R., Effectiveness of an oral versus sublingual loading dose of nifedipine for tocolysis, International Journal of Gynecology & Obstetrics, 148, 3, 2020. Crossref
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Ortiz Andrea C., Morales Javier O., Buccal Delivery of Nanoparticles, in Mucosal Delivery of Drugs and Biologics in Nanoparticles, 41, 2020. Crossref
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Benoit Danielle S.W., Overby Clyde T., Sims Jr. Kenneth R., Ackun-Farmmer Marian A., Drug Delivery Systems, in Biomaterials Science, 2020. Crossref
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Leibtag Shlomo, Peshkovsky Alexey, Cannabis extract nanoemulsions produced by high-intensity ultrasound: Formulation development and scale-up, Journal of Drug Delivery Science and Technology, 60, 2020. Crossref
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Morales Javier O., Vuddanda Parameswara R., Velaga Sitaram, Controlled Drug Delivery via the Buccal and Sublingual Routes, in Fundamentals of Drug Delivery, 2021. Crossref
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Wang Zhijun, Chow Moses SS, Overview and appraisal of the current concept and technologies for improvement of sublingual drug delivery, Therapeutic Delivery, 5, 7, 2014. Crossref
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Abdelalim Lamiaa R., Abdallah Ossama Y., Elnaggar Yosra S.R., High efficacy, rapid onset nanobiolosomes of sildenafil as a topical therapy for erectile dysfunction in aged rats, International Journal of Pharmaceutics, 591, 2020. Crossref
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Zhu Changcheng, Lal Manjari, Preclinical Safety and Pharmacokinetics of Heat Stable Oxytocin in Sublingual Fast-Dissolving Tablet Formulation, Pharmaceutics, 14, 5, 2022. Crossref
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Chaves Paula dos Santos, Ourique Aline Ferreira, Frank Luiza Abrahão, Pohlmann Adriana Raffin, Guterres Sílvia Stanisçuaski, Beck Ruy Carlos Ruver, Carvedilol-loaded nanocapsules: Mucoadhesive properties and permeability across the sublingual mucosa, European Journal of Pharmaceutics and Biopharmaceutics, 114, 2017. Crossref
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Cote Brianna, Rao Deepa, Alani Adam W. G., Nanomedicine for Drug Delivery throughout the Alimentary Canal, Molecular Pharmaceutics, 19, 8, 2022. Crossref
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Naguib Marianne J., Makhlouf Amal I. A., Scalable flibanserin nanocrystal-based novel sublingual platform for female hypoactive sexual desire disorder: engineering, optimization adopting the desirability function approach and in vivo pharmacokinetic study, Drug Delivery, 28, 1, 2021. Crossref