Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 36, 2019 Том 35, 2018 Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v18.i4.10
46 pages

Targeted Delivery of Drugs to the Gastrointestinal Tract

E. C. Lavelle
Institute for Immunology, Department of Biology, National University of Ireland Maynooth, Co. Kildare, Ireland; Rowett Research Institute, Bucksburn, Aberdeen, AB21 9SB, Scotland

Краткое описание

The oral route is attractive for drug administration because it is associated with patient acceptability, less stringent production conditions, and lower costs. However, gastrointestinal destruction of labile molecules and low levels of absorption generally render oral delivery of peptides and proteins ineffective. Several strategies have the potential to enhance the efficacy of orally administered drugs. Bioadhesion is an approach for increasing interaction between drugs and the mucosae. Bioadhesive systems can be nonspecific, achieving adhesion via mechanical processes or specific systems that recognize receptors on epithelial cells. Lectins are one group of specific bioadhesives with many suitable properties for targeting of cells in the gastrointestinal tract (GIT). This review assesses the potential of lectins in the delivery of drugs and vaccines to the GIT.


Articles with similar content:

Therapeutic Opportunities in Colon-Specific Drug-Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.24, 2007, issue 2
Avani Amin, Mayur M. Patel, Tejal Shah
Ethosomes: New Prospects in Transdermal Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.20, 2003, issue 1
Biana Godin, Elka Touitou
Engineered PLGA Nanoparticles: An Emerging Delivery Tool in Cancer Therapeutics
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 1
Amit K. Jain, Manasmita Das, Nitin K. Swarnakar, Sanyog Jain
Rationalized Insights on Causes of Rheumatoid Arthritis in the Elderly and Women: Special Emphasis on Treatment Strategies
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 2
Shikha Srivastava, Deependra Singh, Satish Patel, Manju Rawat Singh
Factors Affecting Drug and Gene Delivery: Effects of Interaction with Blood Components
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.19, 2002, issue 3
Makiya Nishikawa, Mitsuru Hashida, Praneet Opanasopit