Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 36, 2019 Том 35, 2018 Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v33.i1.40
pages 77-105

Microsponges: A Pioneering Tool for Biomedical Applications

Amrita Kumari
Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (M.P.), India - 470 003
Ankit Jain
Institute of Pharmaceutical Research, GLA University, 17km Stone, NH-2, Mathura-Delhi Road P.O. Chaumuhan, Mathura, Uttar Pradesh 281406, India
Pooja Hurkat
Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Central University, Sagar (M.P.), India 470 003
Amit Verma
Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (M.P.), India - 470 003
Sanjay Kumar Jain
Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (M.P.), India

Краткое описание

Microparticulate drug delivery systems have been explored across the globe due to their various advantages. In 1987, Won developed microsponge systems (Micsys), also known as solid-phase porous microspheres, having numerous interconnected voids, which serve as non-collapsible residence for bioactive compounds. A Micsys particle ranges from 5 to 300 μm in size and shows a wide range of entrapment efficiency with desired release rates. This topical drug delivery system bestows a controlled release of bioactive compounds into the skin with reduced systemic side effects. Currently, the application fields of this promising system include oral, ocular, pulmonary, and parenteral delivery of bioactive compounds. In the present review, we summarize the updated biomedical application potential of Micsys as an effective drug-delivery vector, including an in-depth explanation of the drug-release kinetic models and drug-release mechanisms. We also discuss different techniques used to prepare a Micsys, along with their advantages and disadvantages. Moreover, in this review, we report a plethora of Micsys details, such as drug candidates and polymers, exploited in this field, along with marketed formulations, characterization methods, clinical perspectives, and patents received. This assembly of detailed literature summaries will contribute to future advances in the development of porous carriers.


Articles with similar content:

Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 6
Eliahu Heldman, Kristin Loomis, Brandon Smith, Anu Puri, Jae-Ho Lee, Amichai Yavlovich, Robert Blumenthal
Intranasal Delivery of Nanotherapeutics/ Nanobiotherapeutics for the Treatment of Alzheimer's Disease: A Proficient Approach
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.36, 2019, issue 5
Namdev L. Dhas, Tejal A. Mehta, Ritu R. Kudarha
Recent Developments in the Use of Bioadhesive Systems for Delivery of Drugs to the Oral Cavity
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 4
John D. Smart
Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Swarna Bale, Mandip Singh, A. Shiva Shankar Reddy, Amit Khurana, Chandraiah Godugu
Tiny Technology Proves Big: A Challenge at Engineering, Medicine and Pharmaceutical Sciences Interface
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 1
Aswini K. Mohapatra, Anjan K. Mahapatra, P. N. Murthy, Supriya Samoju