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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Therapeutic Drug Carrier Systems
Импакт фактор: 2.9 5-летний Импакт фактор: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Печать: 0743-4863
ISSN Онлайн: 2162-660X

Выпуски:
Том 37, 2020 Том 36, 2019 Том 35, 2018 Том 34, 2017 Том 33, 2016 Том 32, 2015 Том 31, 2014 Том 30, 2013 Том 29, 2012 Том 28, 2011 Том 27, 2010 Том 26, 2009 Том 25, 2008 Том 24, 2007 Том 23, 2006 Том 22, 2005 Том 21, 2004 Том 20, 2003 Том 19, 2002 Том 18, 2001 Том 17, 2000 Том 16, 1999 Том 15, 1998 Том 14, 1997 Том 13, 1996 Том 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v17.i1.10
60 pages

The Use and Development of Retroviral Vectors to Deliver Cytokine Genes for Cancer Therapy

Timothy C. Fong
Present address: RPR Gencell, 3825 Bay Center Place, Hayward, CA 94545
Sybille L. Sauter
Chiron Corporation Center for Gene Therapy, 11055 Roselle Street, San Diego CA 92121
Carlos E. Ibanez
Chiron Corporation Center for Gene Therapy, 11055 Roselle Street, San Diego CA 92121
Philip L. Sheridan
Chiron Corporation Center for Gene Therapy, 11055 Roselle Street, San Diego CA 92121
Douglas J. Jolly
Chiron Corporation Center for Gene Therapy, 11055 Roselle Street, San Diego CA 92121

Краткое описание

In this review, we describe technical advancements of retroviral vectors to address issues of safety, liter, and clinical scale manufacturing to produce high-quality retroviral vector preparations that have made direct intratumoral administration of cytokine encoding recombinant vectors a feasible cancer therapy in the clinic. We also review possible further advances in retroviral vector design, which may prove important in expanding these clinical applications.


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