Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Печать: 0893-9675
ISSN Онлайн: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v16.i3-4.80
pages 245-260

Yin Yang 1 in Human Cancer

Sarah Nicholson
Department of Histopathology, Manchester Royal Infirmary, Central Manchester University Hospitals National Health Service Foundation Trust, Manchester, United Kingdom
Helen Whitehouse
Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, United Kingdom
Khimara Naidoo
Academic Foundation Programme, St Thomas’ Hospital, Guys and St Thomas’ National Health Service Foundation Trust, London, United Kingdom
Richard Byers
University of Manchester

Краткое описание

The transcription factor Yin Yang (YY) 1 controls many divergent cellular processes, including cell proliferation and apoptosis. These are key to cancer development, as a consequence of which its expression has been studied in an increasingly wide range of human cancers, including lymphoma, breast, prostate, colon, ovarian, cervical, and brain cancers, osteosarcoma, rhabdomyosarcoma, and leukemia. It is a regulatory transcription factor for a wide range of genes, including genes involved in control of the cell cycle and apoptosis, and it can act either to upregulate or downregulate downstream gene expression, depending on the cellular environment, cofactors, and the gene targeted. Its expression has been associated with development of a malignant phenotype in some human cancers; tumor progression, including metastasis; and survival. However, as data on its prognostic significance has become available for more human cancers, its role in tumor progression has become controversial; there is conflicting data on its association with outcome, with some studies showing a favorable and others an unfavorable association. This is probably because of the many different roles YY1 plays in control of proliferation and apoptosis, one or the other of which may be more prominent in any given tumor. These studies are reviewed to give an overview of the increasingly recognized importance of YY1 in human tumorigenesis.


Articles with similar content:

YY1 as a Therapeutic Target in Cancer
Onco Therapeutics, Vol.1, 2010, issue 1-2
Khimara Naidoo, Richard J. Byers
Possible Role of Epidermal Growth Factor Receptors in the Therapy of Pancreatic Cancer
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 4
R. S. R. Murthy, Suresh P. Vyas, Manish K. Gupta, Sahil Aggarwal, Swati Gupta
The Effects of Nrf2 on Tumor Angiogenesis: A Review of the Possible Mechanisms of Action
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 2
Wenguang Ye, Mingxin Zhang, Suna Zhou, Jun liang
A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 5-6
Yuhao Wang, Benjamin Bonavida
Aberrant B-Raf Signaling in Human Cancer − 10 Years from Bench to Bedside
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 1
Michael Roring, Tilman Brummer