Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Печать: 0893-9675
ISSN Онлайн: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v7.i3-4.40
pages 205-226

The Role of Metalloproteinases and Their Inhibitors in Hematological Disorders

Liliana Guedez
Laboratory of Pathology, National Cancer Institute, National Institutes of Health
Megan S. Lim
Laboratory of Pathology, National Cancer Institute, National Institutes of Health
William G. Stetler-Stevenson
Laboratory of Pathology, National Cancer Institute, National Institutes of Health

Краткое описание

The balance between the activities of matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) is an important control point during the turnover of the extracellular matrix. Previous studies have demonstrated that an uncontrolled rate of production of these proteins leads to various pathological conditions. Overexpression of MMPs by malignant cells can increase the invasive behavior of solid tumors and their metastatic potential. In an increasing number of reports, it has become evident that expression of MMPs and TIMPs is not restricted to solid tumors. Normal and malignant hematological cells also express these proteins and play a pivotal role in the hematological-cell physiology. In addition to modifying the extracellular matrix, MMPs and TIMPs exert other functions in hematological cells, including growth-factor activity, removal of cell-surface receptors, and autoimmunity. The goal of this review is to gather recent studies concerning the properties of MMPs and TIMPs in hematological cells, their regulation of gene expression, their cellular distribution, and their potential role in the pathogenesis of hematological disorders such as inflammation and neoplasia.

Articles with similar content:

Mechanisms of p53-Mediated Apoptosis
Critical Reviews™ in Oncogenesis, Vol.9, 1998, issue 1
Han-Fei Ding, David E. Fisher
Involvement of Yin Yang 1 (YY1) Expression in T-Cell Subsets Differentiation and Their Functions: Implications in T Cell-Mediated Diseases
Critical Reviews™ in Immunology, Vol.39, 2019, issue 6
Feodora Roxanne Kosasih, Benjamin Bonavida
Recurrent Fusion Oncogenes in Carcinomas
Critical Reviews™ in Oncogenesis, Vol.12, 2006, issue 3-4
Manuel R. Teixeira
The Activated NF-κB-Snail-RKIP Circuitry in Cancer Regulates Both the Metastatic Cascade and Resistance to Apoptosis by Cytotoxic Drugs
Critical Reviews™ in Immunology, Vol.29, 2009, issue 3
Katherine Wu, Benjamin Bonavida
Possible Role of Epidermal Growth Factor Receptors in the Therapy of Pancreatic Cancer
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 4
R. S. R. Murthy, Suresh P. Vyas, Manish K. Gupta, Sahil Aggarwal, Swati Gupta