Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Печать: 0893-9675
ISSN Онлайн: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2015013668
pages 301-314

Physiological, Tumor, and Metastatic Niches: Opportunities and Challenges for Targeting the Tumor Microenvironment

Meera Murgai
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Amber Giles
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Rosandra Kaplan
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Краткое описание

The primary tumor niche and the related but distinct premetastatic/metastatic niche comprise a number of essential players, including immune cells, stromal cells, and extracellular matrix. The cross-talk between these components is key to tumor progression. Many of these cell types and signaling pathways in the tumor microenvironment also are found in physiological and stem cell niches, such as the bone marrow, colonic crypt, and skin bulge. Here they play tightly regulated roles in wound healing and tissue homeostasis. Understanding the similarities and differences between these distinct niches may better inform our ability to therapeutically target the tumor microenvironment. In this review we discuss a number of tumor and metastatic niche components as they relate to stem cell niches and highlight potential therapeutic strategies in pediatric cancers.


Articles with similar content:

Cell Signaling Pathways Related to Epithelial Mesenchymal Transition in Cancer Metastasis
Critical Reviews™ in Oncogenesis, Vol.24, 2019, issue 1
Sevinc Inan, Mürvet Hayran
Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 1
Shuying Yang, Wei Chen, Carrie S. Soltanoff, Yi-Ping Li
Regulation of Chemokine Expression in the Tumor Microenvironment
Critical Reviews™ in Immunology, Vol.34, 2014, issue 2
Anton V. Gorbachev, Robert L. Fairchild
BMP Signaling Pathways in Cartilage and Bone Formation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.11, 2001, issue 1-3
Andrea Hoffmann, Gerhard Gross
Transcriptional Regulation during Mesenchymal Cell Differentiation: The Role of Coactivators
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 2
Rene St-Arnaud