Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Печать: 0893-9675
ISSN Онлайн: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2017021071
pages 13-21

The Role of Transcription Factor YY1 in the Biology of Cancer

Neeraj Agarwal
Department of Pharmacology, University of Colorado, Denver, Colorado; Department of Surgery (Urology), University of Colorado, Denver, Colorado
Dan Theodorescu
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA; Department of Pharmacology, University of Colorado, Denver, Colorado; Department of Surgery (Urology), University of Colorado, Denver, Colorado; University of Colorado Comprehensive Cancer Center, Denver, Colorado

Краткое описание

The transcription factor Yin Yang 1 (YY1) is a ubiquitously expressed protein involved in several biological functions, including embryogenesis, differentiation, replication, and cellular proliferation. YY1 can both activate and repress transcription depending on its interactions with other transcription factors and co-factors. It affects the transcription of a large number of mammalian and viral genes. In this review, we focus on the role of YY1 in cancer biology, including its expression, function, regulation by other upstream factors, and some of its more significant downstream effectors. We also discuss its context-dependent and tumor-specific role in human cancer progression, roles as a prognostic marker, and how its interactions with other cancer-associated factors can be exploited to develop novel targeted therapies.


Articles with similar content:

Tumor Protein D52 Overexpression and Gene Amplification in Cancers from a Mosaic of Microarrays
Critical Reviews™ in Oncogenesis, Vol.14, 2008, issue 1
Jayne R. Hardy, Jennifer A. Byrne, Judith Weidenhofer, Keerthi Thamotharampillai, Mona Shehata
Targeting the Regulatory Machinery of BIM for Cancer Therapy
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 2
Steven Grant, Hisashi Harada
Involvement of Yin Yang 1 (YY1) Expression in T-Cell Subsets Differentiation and Their Functions: Implications in T Cell-Mediated Diseases
Critical Reviews™ in Immunology, Vol.39, 2019, issue 6
Feodora Roxanne Kosasih, Benjamin Bonavida
The Forgotten YY2 in Reported YY1 Expression Levels in Human Cancers
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Samantha Kaufhold, Nabil Aziz , Benjamin Bonavida
Genetic and Epigenetic Control of RKIP Transcription
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 6
Milad S. Bitar, Kevin Qin, Kam C. Yeung, Fahd Al-Mulla, Hanna Tegegne, Ila Datar, Robert J. Trumbly