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Critical Reviews™ in Oncogenesis
Главный редактор: Benjamin Bonavida (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0893-9675

ISSN Онлайн: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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The Oncogenic Role of Human Papillomavirus Proteins

Том 7, Выпуск 1-2, 1996, pp. 1-18
DOI: 10.1615/CritRevOncog.v7.i1-2.10
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Краткое описание

Each human papillomavirus (HPV) type is genotypically distinct and infects epithelial cells at unique anatomic sites. Among the HPV types described, a subgroup is associated with genital disease and a subset of these is found in 90% of genital cancers. Although in benign infections the viral genome is present as an episome. in cancers it is integrated. The integration event invariably results in the expression of two viral proteins, E6 and E7. These two proteins are capable of transforming cells individually and cooperate to immortalize primary human epithelial cells. Molecular analysis has revealed that the E6 protein encoded by the HPV "high risk" types prevalent in cancers forms a tripartite complex with the p53 tumor suppressor protein and a cellular protein termed E6-AP, resulting in the degradation of p53. The E7 protein encoded by "high-risk" HPV types shows high-affinity association with the retinoblastoma tumor suppressor, pRb. The E7 protein associates also with other cellular factors known to play a role in cell cycle regulation. This review discusses the evidence, molecular and biological, in vitro and in vivo, supporting a direct role for the "high-risk" HPV type encoded E6 and E7 proteins in cervical carcinogenesis.

ЦИТИРОВАНО В
  1. Pulitzer Melissa, Molecular Diagnosis of Infection-Related Cancers in Dermatopathology, Seminars in Cutaneous Medicine and Surgery, 31, 4, 2012. Crossref

  2. Zumbach Klaus, Kisseljov Fjodor, Sacharova Olga, Shaichaev Gadzi, Semjonova Ludmila, Pavlova Larissa, Pawlita Michael, Antibodies against oncoproteins E6 and E7 of human papillomavirus types 16 and 18 in cervical-carcinoma patients from Russia, International Journal of Cancer, 85, 3, 2000. Crossref

  3. Suarez Patricia A., Adler-Storthz Karen, Luna Mario A., El-Naggar Adel K., Abdul-Karim Fadi W., Batsakis John G., Papillary squamous cell carcinomas of the upper aerodigestive tract: A clinicopathologic and molecular study, Head & Neck, 22, 4, 2000. Crossref

  4. IDE Akiko, FUJII Michihiko, NAKABABASHI Kazuhiko, AYUSAWA Dai, Suppression of Senescence in Normal Human Fibroblasts by Introduction of Dominant-Negative p53 Mutants or Human Papilloma Virus Type 16 E6 Protein, Bioscience, Biotechnology, and Biochemistry, 62, 7, 1998. Crossref

  5. Lin W.Michael, Ashfaq Raheela, Michalopulos Eugenia A., Maitra Anirban, Gazdar Adi F., Muller Carolyn Y., Molecular Papanicolaou tests in the twenty-first century: Molecular analyses with fluid-based Papanicolaou technology, American Journal of Obstetrics and Gynecology, 183, 1, 2000. Crossref

  6. Aguayo F, Castillo A, Koriyama C, Higashi M, Itoh T, Capetillo M, Shuyama K, Corvalan A, Eizuru Y, Akiba S, Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile, British Journal of Cancer, 97, 1, 2007. Crossref

  7. Rorke Ellen A., Zhang Desheng, Choo C.K., Eckert Richard L., Jacobberger James W., TGF-β-Mediated Cell Cycle Arrest of HPV16-Immortalized Human Ectocervical Cells Correlates with Decreased E6/E7 mRNA and Increased p53 and p21WAF-1 Expression, Experimental Cell Research, 259, 1, 2000. Crossref

  8. Silins Ilvars, Avall-Lundqvist Elisabeth, Tadesse Amha, Jansen Kathrin U., Stendahl Ulf, Lenner Per, Zumbach Klaus, Pawlita Michael, Dillner Joakim, Frankendal Bo, Evaluation of Antibodies to Human Papillomavirus as Prognostic Markers in Cervical Cancer Patients, Gynecologic Oncology, 85, 2, 2002. Crossref

  9. Wang Wei-Ming, Chung Min-Huey, Huang Shih-Ming, Regulation of nuclear receptor activities by two human papillomavirus type 18 oncoproteins, E6 and E7, Biochemical and Biophysical Research Communications, 303, 3, 2003. Crossref

  10. Brentjens Mathijs H, Yeung-Yue Kimberly A, Lee Patricia C, Tyring Stephen K, Human papillomavirus: a review, Dermatologic Clinics, 20, 2, 2002. Crossref

  11. Murakami Akira, Yamayoshi Asako, Iwase Reiko, Nishida Jun-ichi, Yamaoka Tetsuji, Wake Norio, Photodynamic antisense regulation of human cervical carcinoma cell growth using psoralen-conjugated oligo(nucleoside phosphorothioate), European Journal of Pharmaceutical Sciences, 13, 1, 2001. Crossref

  12. Braun Klaus, Ehemann Volker, Waldeck Waldemar, Pipkorn Rüdiger, Corban-Wilhelm Heike, Jenne Jürgen, Gissmann Lutz, Debus Jürgen, HPV18 E6 and E7 genes affect cell cycle, pRB and p53 of cervical tumor cells and represent prominent candidates for intervention by use peptide nucleic acids (PNAs), Cancer Letters, 209, 1, 2004. Crossref

  13. Ke Li Dao, Adler-Storthz K, Follen Mitchell M, Clayman G.L, Chen Zhuo, Expression of human papillomavirus E7 mRNA in human oral and cervical neoplasia and cell lines☆☆Supported by NIH grants R29 CA72427 (Z.C.), R55 DE OD10846 (K.A-S.), and P50DE11906 (K.A-S. and G.L.C.)., Oral Oncology, 35, 4, 1999. Crossref

  14. Liu Shuqing, Tian Yuxiang, Greenaway Frederick T., Sun Ming-Zhong, A C-terminal hydrophobic, solvent-protected core and a flexible N-terminus are potentially required for human papillomavirus 18 E7 protein functionality, Biochimie, 92, 7, 2010. Crossref

  15. Ross Dennis W., Cancer: The Emerging Molecular Biology, Hospital Practice, 35, 1, 2000. Crossref

  16. Underbrink Michael P., Hoskins Stephen L., Pou Anna M., Albrecht Thomas, Viral interaction: a possible contributing factor in head and neck cancer progression, Acta Oto-Laryngologica, 128, 12, 2008. Crossref

  17. Severson Jessica, Evans Tanya Y., Lee Patricia, Chan Teh-Sheng, Arany Istvan, Tyring Stephen K., Human Papillomavirus Infections: Epidemiology, Pathogenesis, and Therapy, Journal of Cutaneous Medicine and Surgery, 5, 1, 2001. Crossref

  18. Alemi Mansour, Andersson Sonja, Sällström Jan, Wilander Erik, Rapid Test for Identification of a Human Papillomavirus 16 E6 L83V Variant, Diagnostic Molecular Pathology, 8, 2, 1999. Crossref

  19. Zumbach Klaus, Hoffmann Markus, Kahn Tomas, Bosch Franz, Gottschlich Stefan, G�r�gh Tibor, Rudert Heinrich, Pawlita Michael, Antibodies against oncoproteins E6 and E7 of human papillomavirus types 16 and 18 in patients with head-and-neck squamous-cell carcinoma, International Journal of Cancer, 85, 6, 2000. Crossref

  20. Nogueira Marcela O., Hošek Tomáš, Calçada Eduardo O., Castiglia Francesca, Massimi Paola, Banks Lawrence, Felli Isabella C., Pierattelli Roberta, Monitoring HPV-16 E7 phosphorylation events, Virology, 503, 2017. Crossref

  21. Walts Ann E., Thomas Premi, Correlation of manual screening and automated (AutoPap 300) analysis of conventional cervicovaginal smears with HPV typing using Digene HC II assay, Diagnostic Cytopathology, 29, 5, 2003. Crossref

  22. Alaoui-Jamali Moulay, Saad Amine, Batist Gerald, Growth Factor Receptor Signaling, DNA Damage Response, and Cancer Cell Susceptibility to Chemotherapy and Relapses, in Advances in DNA Repair in Cancer Therapy, 2013. Crossref

  23. Colby Candice, Klein Adam M., Papillary Squamous Cell Carcinoma of thec Larynx, Ear, Nose & Throat Journal, 90, 8, 2011. Crossref

  24. Ross Dennis W., Squamous Cell Carcinoma of the Uterine Cervix, in Introduction to Oncogenes and Molecular Cancer Medicine, 1998. Crossref

  25. Menzo Stefano, Monachetti Alessia, Trozzi Caterina, Ciavattini Andrea, Carloni Guido, Varaldo Pietro E., Clementi Massimo, Identification of Six Putative Novel Human Papillomaviruses (HPV) and Characterization of Candidate HPV Type 87, Journal of Virology, 75, 23, 2001. Crossref

  26. Yin XiaoYing, Grove Linnette, Datta Nabanita S, Long Michael W, Prochownik Edward V, C-myc overexpression and p53 loss cooperate to promote genomic instability, Oncogene, 18, 5, 1999. Crossref

  27. Dohn Michael, Zhang Shungzhen, Chen Xinbin, p63α and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes, Oncogene, 20, 25, 2001. Crossref

  28. Badillo-Almaraz Isaías, Zapata-Benavides Pablo, Saavedra-Alonso Santiago, Zamora-Avila Diana, Reséndez-Pérez Diana, Tamez-Guerra Reyes, Herrera-Esparza Rafael, Rodríguez-Padilla Cristina, Human Papillomavirus 16/18 Infections in Lung Cancer Patients in Mexico, Intervirology, 56, 5, 2013. Crossref

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