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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Печать: 0278-940X
ISSN Онлайн: 1943-619X

Выпуски:
Том 47, 2019 Том 46, 2018 Том 45, 2017 Том 44, 2016 Том 43, 2015 Том 42, 2014 Том 41, 2013 Том 40, 2012 Том 39, 2011 Том 38, 2010 Том 37, 2009 Том 36, 2008 Том 35, 2007 Том 34, 2006 Том 33, 2005 Том 32, 2004 Том 31, 2003 Том 30, 2002 Том 29, 2001 Том 28, 2000 Том 27, 1999 Том 26, 1998 Том 25, 1997 Том 24, 1996 Том 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v37.i4-5.10
pages 283-320

Molecular Aspects of Cardiac Differentiation in Embryonic Stem Cells

Prasenjit Sarkar
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA
Balaji M. Rao
Department of Chemical and Biomolecular Engineering, North Carolina State University, USA

Краткое описание

Embryonic stem cells (ESCs) are culture-adapted pluripotent cells derived from the inner cell mass of the blastocyst-stage embryo. ESCs provide unique opportunities to study the molecular basis of the process of differentiation that gives rise to all the somatic cell types of the body, including cells of the cardiac lineages. Many protocols have been established to obtain cells of the cardiac lineage from ESCs in vitro. More recently, a clearer picture of the regulatory networks governing cardiac differentiation has begun to emerge. Herein, we summarize the current methods to obtain cells of the cardiac lineages from ESCs and present a review of the signaling pathways, transcription factors, and target genes involved in cardiac differentiation.