Доступ предоставлен для: Guest
Critical Reviews™ in Biomedical Engineering

Выходит 6 номеров в год

ISSN Печать: 0278-940X

ISSN Онлайн: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Corneal Cross-Linking: Engineering a Predictable Model

Том 42, Выпуск 3-4, 2014, pp. 229-248
DOI: 10.1615/CritRevBiomedEng.2014011715
Get accessGet access

Краткое описание

Corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A (UVA) light has become a viable treatment for keratoconus. In cases in which corneal transplant may have previously been a patient's primary treatment option, the results of CXL have varied from decreased progression of the disease to marked regression characterized by improvement in visual acuity. In addition, changes to the original protocol have been tested that include leaving the epithelium intact and increasing the UVA intensity while decreasing the exposure time. The variation in results and protocols underscores the need for a greater understanding of the procedure and its effects. Ideally, a complete definition of the effects of CXL will lead to patient-specific treatment through highly controlled delivery methods of riboflavin and UVA light and complete mathematical models for predicting the final shape and refractive effect of the cornea. Thus, in this review, we aimed to describe the current techniques for measuring the effect of CXL, with a focus on material property changes, while highlighting the challenge of engineering a predictable mathematical model of the procedure and the resulting clinical outcome.

ЦИТИРОВАНО В
  1. Chen Peng, Chen Xun, Hepfer R. Glenn, Damon Brooke J., Shi Changcheng, Yao Jenny J., Coombs Matthew C., Kern Michael J., Ye Tong, Yao Hai, A noninvasive fluorescence imaging-based platform measures 3D anisotropic extracellular diffusion, Nature Communications, 12, 1, 2021. Crossref

Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain