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ISSN Печать: 0278-940X
ISSN Онлайн: 1943-619X
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Preface
Краткое описание
This issue of Journal of Critical Reviews in Biomedical Engineering contains five review articles on the current state and contribution of modeling of signal transduction at different scales in cardiovascular systems. These review papers address diverse issues such as oxidative and nitrosative stress, electrophysiology, cell signaling and metabolism, the regulation of local perfusion and oxygenation, several signaling pathways in the microcirculation that involve NO, and calcium and mitochondrial energy transduction. They highlight the contribution of computational modeling to our understanding of cardiovascular systems from molecules to whole organ and in physiology and pathophysiology and therapeutic approaches. The reviews provide a reader the comprehensive view of challenges and opportunities in modeling in cardiovascular systems.