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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Печать: 0278-940X
ISSN Онлайн: 1943-619X

Выпуски:
Том 47, 2019 Том 46, 2018 Том 45, 2017 Том 44, 2016 Том 43, 2015 Том 42, 2014 Том 41, 2013 Том 40, 2012 Том 39, 2011 Том 38, 2010 Том 37, 2009 Том 36, 2008 Том 35, 2007 Том 34, 2006 Том 33, 2005 Том 32, 2004 Том 31, 2003 Том 30, 2002 Том 29, 2001 Том 28, 2000 Том 27, 1999 Том 26, 1998 Том 25, 1997 Том 24, 1996 Том 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v38.i2.50
pages 189-200

Are Microfluidics-Based Blood Viscometers Ready for Point-of-Care Applications? A Review

Peng Kai Ong
Division of Bioengineering and Department of Surgery, National University of Singapore, Singapore
Dohyung Lim
Gernotechnology Center, Korea Institute of Industrial Technology, Cheonan, Chungnam, Korea
Sangho Kim
Department of Bioengineering, National University of Singapore, Singapore 117575

Краткое описание

In recent years, the engineering of blood viscometers for the diagnosis, prognosis, and prevention of cardiovascular and other diseases has been the subject of significant research interest. Conventional blood viscometers such as rotational viscometers and capillary viscometers typically rely on mechanical techniques in quantifying whole-blood viscosity, a process in which resistance to blood flow is measured in response to an applied force. The direct applicability of conventional viscometers as point-of-care diagnostic and clinical tools is subject to several limitations mainly related to their macro-structural features that augment the sampling size and reduce portability. The development of new fabrication technologies to scale down experimental processes has opened up the reality of miniaturizing existing concepts of blood viscometers into microchips, and paves the road for future development of blood viscometers. These micro-blood viscometers are advantageous because they use very small sample volumes for quick, routine clinical purposes. The easy fabrication of microsystems and large-scale production not only result in a lower cost, but also render these devices portable and disposable, both of which are highly desirable for clinical applications. The underlying challenges of these devices are associated with red blood cell clogging, measurement stability, reliability, and reproducibility. The present review discusses the state-of-the-art and emerging trends in the field of microfluidics to provide elegant solutions for quantifying blood viscosity with vastly improved efficacy and with the potential for use at the patient’s bedside.


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