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Critical Reviews™ in Biomedical Engineering

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ISSN Печать: 0278-940X

ISSN Онлайн: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Asymmetry in Signal Oscillations Contributes to Efficiency of Periodic Systems

Том 44, Выпуск 3, 2016, pp. 193-211
DOI: 10.1615/CritRevBiomedEng.2017019658
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Краткое описание

Oscillations are an important feature of cellular signaling that result from complex combinations of positive- and negative-feedback loops. The encoding and decoding mechanisms of oscillations based on amplitude and frequency have been extensively discussed in the literature in the context of intercellular and intracellular signaling. However, the fundamental questions of whether and how oscillatory signals offer any competitive advantages−and, if so, what−have not been fully answered. We investigated established oscillatory mechanisms and designed a study to analyze the oscillatory characteristics of signaling molecules and system output in an effort to answer these questions. Two classic oscillators, Goodwin and PER, were selected as the model systems, and corresponding no-feedback models were created for each oscillator to discover the advantage of oscillating signals. Through simulating the original oscillators and the matching no-feedback models, we show that oscillating systems have the capability to achieve better resource-to-output efficiency, and we identify oscillatory characteristics that lead to improved efficiency.

Ключевые слова: PER, Goodwin, encoding, decoding, oscillating signals
ЦИТИРОВАНО В
  1. Androulakis Ioannis P., Circadian rhythms and the HPA axis: A systems view , WIREs Mechanisms of Disease, 13, 4, 2021. Crossref

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