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Critical Reviews™ in Biomedical Engineering
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN Печать: 0278-940X
ISSN Онлайн: 1943-619X

Выпуски:
Том 47, 2019 Том 46, 2018 Том 45, 2017 Том 44, 2016 Том 43, 2015 Том 42, 2014 Том 41, 2013 Том 40, 2012 Том 39, 2011 Том 38, 2010 Том 37, 2009 Том 36, 2008 Том 35, 2007 Том 34, 2006 Том 33, 2005 Том 32, 2004 Том 31, 2003 Том 30, 2002 Том 29, 2001 Том 28, 2000 Том 27, 1999 Том 26, 1998 Том 25, 1997 Том 24, 1996 Том 23, 1995

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.2016016066
pages 455-471

Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs

Bo Wang
Department of Biological Engineering and College of Veterinary Medicine, Mississippi State University, Mississippi; Department of Biomedical Engineering, Alabama State University, Montgomery, Alabama
Sourav S. Patnaik
Department of Biological Engineering and College of Veterinary Medicine, Mississippi State University, Mississippi
Bryn Brazile
Department of Biological Engineering and College of Veterinary Medicine, Mississippi State University, Mississippi
J. Ryan Butler
Department of Biological Engineering and College of Veterinary Medicine, Mississippi State University, Mississippi
Andrew Claude
Department of Biological Engineering and College of Veterinary Medicine, Mississippi State University, Mississippi
Ge Zhang
Department of Biomedical Engineering, University of Akron, Ohio
Jianjun Guan
Department of Material Science and Technology, Ohio State University, Columbus, Ohio
Yi Hong
Department of Bioengineering, University of Texas at Arlington, Arlington, Texas
Jun Liao
Department of Biological Engineering and College of Veterinary Medicine, Mississippi State University, Mississippi

Краткое описание

Myocardial infarction (MI) causes massive heart muscle death and remains a leading cause of death in the world. Cardiac tissue engineering aims to replace the infarcted tissues with functional engineered heart muscles or revitalize the infarcted heart by delivering cells, bioactive factors, and/or biomaterials. One major challenge of cardiac tissue engineering and regeneration is the establishment of functional perfusion and structure to achieve timely angiogenesis and effective vascularization, which are essential to the survival of thick implants and the integration of repaired tissue with host heart. In this paper, we review four major approaches to promoting angiogenesis and vascularization in cardiac tissue engineering and regeneration: delivery of pro-angiogenic factors/molecules, direct cell implantation/cell sheet grafting, fabrication of prevascularized cardiac constructs, and the use of bioreactors to promote angiogenesis and vascularization. We further provide a detailed review and discussion on the early perfusion design in nature-derived biomaterials, synthetic biodegradable polymers, tissue-derived acellular scaffolds/whole hearts, and hydrogel derived from extracellular matrix. A better understanding of the current approaches and their advantages, limitations, and hurdles could be useful for developing better materials for future clinical applications.


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