Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Plasma Medicine
SJR: 0.278 SNIP: 0.183 CiteScore™: 0.57

ISSN Печать: 1947-5764
ISSN Онлайн: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2016015688
pages 205-221

Biological Effects and Enhancement of Percutaneous Absorption on Skin by Atmospheric Microplasma Irradiation

Kazuo Shimizu
Organization for Innovation and Social Collaboration, Shizuoka University, 3-5-1 Johoku, Hamamatsu, 4328561, Japan

Краткое описание

Atmospheric plasma is attracting interest for medical applications and clinical phases. We adduce the following questions to guide the future research in plasma medicine.
1. Is plasma medicine an effective method for treating various symptoms?
2. If not, what combination of drugs in addition to plasma irradiation will be required?
3. Can plasma irradiation be an effective method for drug administration?
In this study, we explored the feasibility of using atmospheric microplasma irradiation to enhance percutaneous absorption of drugs, as an alternative delivery method to conventional hypodermic needles, to treat various symptoms, such as those associated with Alzheimer's disease. Pig skin was used as a biological sample, exposed to microplasma irradiation, and analyzed by attenuated total reflection-Fourier transform infrared spectroscopy. A tape stripping test, which is a representative method for evaluating skin barrier performance, was also conducted for comparison. Transepidermal water loss was measured to quantify water evaporation from the inside of the body through the skin barrier. The results show that the stratum corneum could be chemically and physically modified by microplasma irradiation. Physical damage to the skin by microplasma irradiation and plasma jets was also assessed by observing the skin surface. The results suggest that microplasma irradiation has the potential to enhance percutaneous absorption.


Articles with similar content:

Live Pig Skin Tissue and Wound Toxicity of Cold Plasma Treatment
Plasma Medicine, Vol.1, 2011, issue 1
Suresh G. Joshi, Danil Dobrynin, Ari D. Brooks, Kimberly Wasko, Andrew Wu, Essel Dumani, Sameer Kalghatgi, Sin Park, Natalie Chernets, Rachel Sensenig, Robert Ownbey
Transdermal Iontophoresis: Impact on Skin Integrity as Evaluated by Various Methods
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 4
Senshang Lin, Maansi G. Kumar
Improving the Management of Bladder Cancer with Fluorescence Cystoscopy
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
H. Barton Grossman
New Technologies in Using Recombinant Attenuated Salmonella Vaccine Vectors
Critical Reviews™ in Immunology, Vol.30, 2010, issue 3
Yuhua Li, Bronwyn Gunn, Soo-Young Wanda, Wei Kong, Wei Xin, Shifeng Wang, Roy Curtiss III
Non-Thermal Atmospheric Dielectric Barrier Discharge Plasma, Medical Application Studies in Thailand
Plasma Medicine, Vol.6, 2016, issue 3-4
Chanchai Chutsirimongkol, Wasini Techawatthanawisan, Treenuch Kundilokchai, Dheerawan Boonyawan, Paisal Rummaneethorn, Apirag Chuangsuwanit, Chayanid Bunsaisup, Pannapa Powthong, Wicharn Kirdwichai, Niwat Polnikorn