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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2014007884
pages 89-100

CTLA-4 SNPs (CT60A/G, -1722T/C, -1661G/A, and -318C/T) and Systemic Lupus Erythematosus: A Meta-Analysis

Yun Zhu
Department of Rheumatology and Immunology, Drum Tower Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China
Jing Wang
Department of Hematology, Drum Tower Hospital, Nanjing, Jiangsu, PR China
Xuebing Feng
Department of Rheumatology and Immunology, Drum Tower Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China

Краткое описание

In this meta-analysis, we investigated the association between CTLA-4 polymorphisms (CT60A/G, -1722T/C, -1661G/A, and -318C/T) and SLE susceptibility. Data were extracted independently by two reviewers. The odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in fixed or random effects models. Seventeen studies involving of 3931 cases and 4619 controls were identified. Significant association of promoter -1722T/C polymorphism and SLE was observed for TT vs. CC (OR=1.63, 95% CI 1.63-2. 30, P<0.05) in the overall study population and in the Asians subgroups (OR=2. 18, 95% CI 1.70−2. 81, P<0.05); the OR for the allele T vs. C in Asians was 1.66 (95% CI 1.33−2. 07, P<0.05). For the CT60A/G polymorphism, significant association was observed for AA vs. AG (OR=0.64, 95% CI 0.46−0.88, P<0.05) in Asians. These results suggest that -1722T/C and CT60A/G polymorphisms in CTLA-4 are associated with SLE, particularly in Asians.


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