Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 30, 2020 Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2019026812
pages 599-607

Stem Cells in Liver Fibrosis: Translational Challenges and Opportunities

Muhammad Masoud
Government College University, Faisalabad.
Khushbakht Aliya
Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan
Muhammad Tariq
Department of Biotechnology, Mirpur University of Science and Technology, Azad Jammu and Kashmir, Pakistan

Краткое описание

The liver is a vital organ with high regenerative ability that compensates cellular loss in liver injury. However, in chronic injuries ECM accumulates and leads to loss of cells and normal function. Liver transplantation is an effective therapy for patients with liver failure, but because of a lack of liver donors, research focus has moved toward the use of stem cells to regenerate the liver. This review emphasizes the potential of different types of stem cell to be used in liver regeneration.

ЛИТЕРАТУРА

  1. Greenbaum LE, Wells RG. The role of stem cells in liver repair and fibrosis. Int J Biochem Cell Biol. 2011;43(2):222-9.

  2. Tsai PC, Fu TW, Chen YMA, Ko TL, Chen TH, Shih YH, Hung SC, Fu YS. The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis. Liver Transplant. 2009;15(5):484-95.

  3. Kim J-Y, Jeon HB, Yang YS, Oh W, Chang JW. Application of human umbilical cord blood-derived mesenchymal stem cells in disease models. World J Stem Cells. 2010;2(2):34.

  4. Zhou W-C, Zhang Q-B, Qiao L. Pathogenesis of liver cirrhosis. World J Gastroenterol. 2014;20(23):7312.

  5. Baranova A, Lal P, Birerdinc A, Younossi ZM. Noninvasive markers for hepatic fibrosis. BMC Gastroenterol. 2011;11(1):91.

  6. Liu C, Hu Y, Xu L, Liu C, Liu P. Effect of Fuzheng Huayu formula and its actions against liver fibrosis. Chin Med. 14. 2009;4(1):12.

  7. Xu J, Liu X, Koyama Y, Wang P, Lan T, Kim I-G, Kim IH, Ma H-Y, Kisseleva T. The types of hepatic myofibroblasts 15. contributing to liver fibrosis of different etiologies. Front Pharmacol. 2014;5:167.

  8. Kisseleva T, Brenner DA. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol. 2007;22(S1):S73-78.

  9. Cheng K, Mahato RI. Gene modulation for treating liver fibrosis. Crit Rev Therap Drug Carrier Systems. 2007; 24(2):93-146.

  10. Rygiel KA, Robertson H, Marshall HL, Pekalski M, Zhao L, Booth TA, Jones DE, Burt AD, Kirby JA. Epithelial mesenchymal transition contributes to portal tract fibro-genesis during human chronic liver disease. Lab Invest. 2008;88(2):112-23.

  11. Dufour J-F, Delellis R, Kaplan MM. Regression of hepatic fibrosis in hepatitis C with long-term interferon treatment. Digest Dis Sci. 1998;43(12):2573-6.

  12. Sobesky R, Mathurin P, Charlotte F, Moussalli J, Olivi M, Vidaud M, Ratziu V, Opolon P, Poynard T. Modeling the impact of interferon alfa treatment on liver fibrosis progression in chronic hepatitis C: a dynamic view. Gastroenterology. 1999;116(2):378-86.

  13. Iimuro Y, Brenner DA. Matrix metalloproteinase gene delivery for liver fibrosis. Pharma Res. 2008;25(2):249-58.

  14. Siddiqui A, Jeevani T, Naga Anusha P, Hima Bindu A. Stem cell therapy for liver diseases. J Stem Cell Res Ther. 2011;1(3):1000111.

  15. Forbes SJ, Newsome PN. New horizons for stem cell therapy in liver disease. J Hepatol. 2012;56(2):496-9.

  16. Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H, Okita K. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology. 2004;40(6):1304-11.

  17. Mirzaei H, Sahebkar A, Sichani LS, Moridikia A, Nazari S, Sadri Nahand J, Salehi H, Stenvang J, Masoudifar A, Mirzaei HR. Therapeutic application of multipotent stem cells. J Cell Physiol. 2014;233(4):2815-23.

  18. Wallace K, Burt AD, Wright MC. Liver fibrosis. Biochem J. 2008;411(1):1-18.

  19. Pinzani M, Rombouts K. Liver fibrosis: from the bench to clinical targets. Digest Liver Dis. 2004;36(4):231-42.

  20. Bataller RN, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115(2):209.

  21. Kisseleva T, Brenner DA. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Hepatol. 2012;56(4):965-72.

  22. Luk JM, Wang X, Liu P, Wong KF, Chan KL, Tong Y, Hui CK, Lau GK, Fan ST. Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation. Liver Int. 2007;27(7):879-90.

  23. Zhang D, Jiang M, Miao D. Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse. PLoS One. 2011;6(2):e16789.

  24. Manojlovic Z, Blackmon J, Stefanovic B. Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis. PLoS One. 2013;8(6):e65897.

  25. Margini C, Vukotic R, Brodosi L, Bernardi M, Andreone P. Bone marrow derived stem cells for the treatment of end-stage liver disease. World J Gastroenterol. 2014;20(27):9098.

  26. Iimuro Y, Brenner DA. Matrix metalloproteinase gene delivery for liver fibrosis. Pharma Res. 2007;25(2):249-58.

  27. Lee CS, Friedman JR, Fulmer JT, Kaestner KH. The initiation of liver development is dependent on Foxa transcription factors. Nature. 2005;435(7044):944-7.

  28. Agarwal S, Holton KL, Lanza R. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells. 2008;26(5):1117-27.

  29. Kubo A, Shinozaki K, Shannon JM, Kouskoff V, Kennedy M, Woo S, Fehling HJ, Keller G. Development of definitive endoderm from embryonic stem cells in culture. Development. 2004;131(7):1651-62.

  30. Wang S, Qu X, Zhao RC. Clinical applications of mesenchymal stem cells. J Hematol Oncol. 2013;5(1):19.

  31. Zhang Z, Lin H, Shi M, Xu R, Fu J, Lv J, Chen L, Lv S, Li Y, Yu S. Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J Gastroenterol Hepatol. 2012;27(s2):112-20.

  32. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418(6893):41-9.

  33. Mareschi K, Ferrero I, Rustichelli D, Aschero S, Gammaitoni L, Aglietta M, Madon E, Fagioli F. Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow. J Cell Biochem. 2006;97(4):744-54.

  34. Shi M, Li J, Liao L, Chen B, Li B, Chen L, Jia H, Zhao RC. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica. 2007;92(7):897-904.

  35. Bi H, Ming L, Cheng R, Luo H, Zhang Y, Jin Y. Liver extracellular matrix promotes BM MSCs hepatic differentiation and reversal of liver fibrosis through activation of integrin pathway. J Tissue Eng Regen Med. 2017 Oct:11(10):2685-2698.

  36. Jang YO, Cho M-Y, Yun C-O, Baik SK, Park K-S, Cha S-K, Chang SJ, Kim MY, Lim YL, Kwon SO. Effect of function-enhanced mesenchymal stem cells infected with decorin-expressing adenovirus on hepatic fibrosis. Stem Cells Trans Med. 2016;5(9):1247-56.

  37. Haldar D, Henderson NC, Hirschfield G, Newsome PN. Mesenchymal stromal cells and liver fibrosis: a complicated relationship. FASEB J. 2016;30(12):3905-28.

  38. Kim M-D, Kim S-S, Cha H-Y, Jang S-H, Chang D-Y, Kim W, Suh-Kim H, Lee J-H. Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis. Exper Mol Med. 2014;46(8):e110.

  39. Itskovitz-Eldor J, Schuldiner M, Karsenti D, Eden A, Yanuka O, Amit M, Soreq H, Benvenisty N. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mol Med. 2000;6(2):88.

  40. Hamazaki T, Iiboshi Y, Oka M, Papst PJ, Meacham AM, Zon LI, Terada N. Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett. 2001;497(1):15-9.

  41. Rambhatla L, Chiu C-P, Kundu P, Peng Y, Carpenter MK. Generation of hepatocyte-like cells from human embryonic stem cells. Cell Transplant. 2003;12(1):1-11.

  42. Cai J, Zhao Y, Liu Y, Ye F, Song Z, Qin H, Meng S, Chen Y, Zhou R, Song X. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology. 2007;45(5):1229-39.

  43. Touboul T, Hannan NR, Corbineau SB, Martinez AL, Martinet CM, Branchereau S, Mainot S, Stricka-Marchand HLN, Pedersen R, Di Santo J. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. Hepatology. 2010;51(5):1754-65.

  44. Lavon N, Benvenisty N. Study of hepatocyte differentiation using embryonic stem cells. J Cell Biochem. 2005;96(6):1193-202.

  45. Teratani T, Yamamoto H, Aoyagi K, Sasaki H, Asari A, Quinn G, Sasaki H, Terada M, Ochiya T. Direct hepatic fate specification from mouse embryonic stem cells. Hepatology. 2005;41(4):836-46.

  46. Basma H, Soto-Gutierrez A, Yannam GR, Liu L, Ito R, Yamamoto T, Ellis E, Carson SD, Sato S, Chen Y, Muirhead D. Differentiation and transplantation of human embryonic stem cell derived hepatocytes. Gastroenterology. 2009;136(3):990-9.

  47. Harn H-J, Lin S-Z, Hung S-H, Subeq Y-M, Li Y-S, Syu W-S, Ding D-C, Lee R-P, Hsieh D-K, Lin P-C. Adipose-derived stem cells can abrogate chemical-induced liver fibrosis and facilitate recovery of liver function. Cell Transplant. 2012;21(12):2753-64.

  48. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Quinn G, Okochi H, Ochiya T. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology. 2007;46(1):219-28.

  49. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kawamata M, Kato T, Okochi H, Ochiya T. IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells. 2008;26(10): 2705-12.

  50. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Osaki M, Kato T, Okochi H, Ochiya T. Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. J Gastroenterol Hepatol. 2009;24(1):70-7.

  51. Sadri A-R, Jeschke MG, Amini-Nik S. Advances in liver regeneration: revisiting hepatic stem/progenitor cells and their origin. Stem Cells Int. 2016;2016:7920897.

  52. Lee KD, Kuo TKC, Whang-Peng J, Chung YF, Lin CT, Chou SH, Chen JR, Chen YP, Lee OKS. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology. 2004;40(6):1275-84.

  53. Houlihan DD, Newsome PN. Critical review of clinical trials of bone marrow stem cells in liver disease. Gastro-enterology. 2008;135(2):438-50.

  54. Best J, Manka P, Syn W-K, Doll L, van Grunsven LA, Canbay A. Role of liver progenitors in liver regeneration. Hepato Surg Nutr. 2015;4(1):48-58.

  55. Petersen B, Bowen W, Patrene K, Mars W, Sullivan A, Murase NA, Boggs S, Greenberger J, Goff J. Bone marrow as a potential source of hepatic oval cells. Science. 1999;284(5417):1168-70.

  56. Bird T, Lorenzini S, Forbes S. Activation of stem cells in hepatic diseases. Cell Tissue Res. 2008;331(1):283.

  57. Brezillon N, Kremsdorf D, Weiss MC. Cell therapy for the diseased liver: from stem cell biology to novel models for hepatotropic human pathogens. Dis Models Mechan. 2008;1(2-3):113-30.

  58. Farber E. Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3-methyl-4dimethylaminoazo-benzene. Cancer Res. 1956;16(2):142.

  59. Oertel M, Shafritz DA. Stem cells, cell transplantation and liver repopulation. Biochim Biophys Acta Mol Basis Dis. 2008;1782(2):61-74.

  60. Fu Y-S, Shih Y-T, Cheng Y-C, Min M-Y. Transformation of human umbilical mesenchymal cells into neurons in vitro. J Biomed Sci. 2004;11(5):652-60.

  61. Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, Fu YS, Lai MC, Chen CC. Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells. 2004;22(7):1330-7.

  62. Jung KH, Shin HP, Lee S, Lim YJ, Hwang SH, Han H, Park HK, Chung JH, Yim SV. Effect of human umbilical cord blood-derived mesenchymal stem cells in a cirrhotic rat model. Liver Int. 2009;29(6):898-909.

  63. D'ippolito G, Schiller PC, Ricordi C, Roos BA, Howard GA. Age related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J Bone Mineral Res. 1999;14(7):1115-22.

  64. Jeong JA, Gang EJ, Hong SH, Hwang SH, Kim SW, Yang IH, Ahn C, Han H, Kim H. Rapid neural differentiation of human cord blood-derived mesenchymal stem cells. Neuroreport. 2004;15(11):1731-4.

  65. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Saito K, Hara Y, Teramoto K, Arii S, Sato C, Takase K. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells. 2003;21(2): 217-27.

  66. Liu H, Kim Y, Sharkis S, Marchionni L, Jang Y-Y. In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins. Sci Trans Med. 2011;3(82):82ra39.

  67. Chun YS, Chaudhari P, Jang Y-Y. Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease. Int J Biol Sci. 2010;6(7):796-805.

  68. Liu H, Ye Z, Kim Y, Sharkis S, Jang YY. Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes. Hepatology. 2010;51(5):1810-9.

  69. Blau HM, Brazelton T, Weimann J. The evolving concept of a stem cell: entity or function? Cell. 2001;105(7):829-41.

  70. Jang Y-Y, Collector MI, Baylin SB, Diehl AM, Sharkis SJ. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol. 2004;6(6):532-9.

  71. Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000;31(1):235-40.

  72. Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nature Med. 2000;6(11): 1229-34.