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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
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XRCC1 Arg194Trp and Arg280His Polymorphisms in Bladder Cancer Susceptibility: A Meta-Analysis
Краткое описание
The XRCC1 Arg194Trp and Arg280His polymorphisms were likely to be involved with the development of bladder cancer. However, there had been inconsistent reports of association. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science for relevant articles with a time limit of April 25, 2013. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between the two polymorphisms and bladder cancer susceptibility using a random-effects model. This meta-analysis including 14 case-control studies evaluated the associations between the two XRCC1 polymorphisms and bladder cancer susceptibility. Overall, for Arg194Trp, significant associations were found in TT versus CC (OR = 1.78, 95% CI = 1.12−2.82) and the recessive model (OR = 1.71, 95% CI = 1.11−2.65); for Arg280His, significant associations were also found in AG versus GG (OR = 1.63, 95% CI = 1.24−2.13) and the dominant model (OR = 1.39, 95% CI = 1.07−1.82). When stratified by ethnicity, in Asian population, significant associations were found for Arg194Trp polymorphism in TT versus CC (OR = 2.99, 95% CI = 1.48−6.06), the dominant model (OR = 1.33, 95% CI = 1.03−1.72) and the recessive model (OR = 2.72, 95% CI = 1.36−5.45), and for Arg280His in GA versus GG (OR = 2.13, 95% CI = 1.63−2.97), but no significant associations were found in no-Asian population. This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.
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