Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 2.156 5-летний Импакт фактор: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 30, 2020 Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v11.i1-3.40
18 pages

The Family of Retinoblastoma Proteins

Peter Stiegler
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107
Antonio Giordano
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107

Краткое описание

Our understanding of how the retinoblastoma family members, pRB/p105, pRB2/p130, and pRBL1/p107, regulate cellular properties has progressed significantly. Mechanisms have been described regarding how these proteins utilize properties of additional factors, such as histone deacetylases, to negatively regulate transcription. More importantly, the retinoblastoma proteins have been integrated within multiple cellular pathways, and a complex view has emerged on how the individual members respond to various external and internal stimuli. pRB/p105 is best described in its biochemical properties as well as in the resulting cellular functions. Less is known about pRB2/p130 and pRBL1/p107, but an improved map of their individual as well as redundant functions has been drawn over the last years. In this review we describe general aspects of the properties and functions of the three retinoblastoma family members and their protein-binding partners in cellular growth control.


Articles with similar content:

Deacetylation of Chromatin and Gene Expression Regulation: A New Target for Epigenetic Therapy
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 1-2
Heidi Olzscha, Nicholas B. La Thangue, Semira Sheikh
The Role of the Proto-Oncogene c-myc in B Lymphocyte Differentiation
Critical Reviews™ in Immunology, Vol.32, 2012, issue 4
Ignacio Moreno de Alboran, David Fernandez, Victor Javier Sanchez-Arevalo
Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Mark L. Johnson, Douglas T. Summerfield
Structural and Expression Changes of Septins in Myeloid Neoplasia
Critical Reviews™ in Oncogenesis, Vol.15, 2009, issue 1-2
Nuno Cerveira, Joana Santos, Manuel R. Teixeira
Functions of CD40 and Its Ligand, gp39 (CD40L)
Critical Reviews™ in Immunology, Vol.16, 1996, issue 1
Jon D. Laman, Randolph J. Noelle, Eric Claassen