Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 2.156 5-летний Импакт фактор: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 30, 2020 Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v11.i1-3.30
12 pages

Polymeric Delivery of Proteins and Plasmid DNA for Tissue Engineering and Gene Therapy

Thomas P. Richardson
Departments of 1Biomedical Engineering, and Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109
William L. Murphy
Departments of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109
David J. Mooney
Departments of Biomedical Engineering, Chemical Engineering, and Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109

Краткое описание

In vivo gene expression can be altered by locally delivered DNA and proteins. The ability to deliver bioactive macromolecules, such as proteins and plasmid DNA, over controllable time frames represents a challenging engineering problem. Considerable success has been achieved with polymeric delivery systems that provide the capability to change cell function either acutely or chronically. This review focuses on controlled delivery of proteins and plasmid DNA from polymers and on the effects of controlled delivery on gene expression, and introduces some cell biological and biochemical parameters to be considered when delivering macromolecules to change cell behavior.


Articles with similar content:

Ceramic Drug-Delivery Devices
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.15, 1998, issue 1
Praphulla K. Bajpai, Annie Lasserre
Multifunctional Matrices for Oral Peptide Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.18, 2001, issue 5
Andreas Bernkop-Schnurch, Greg Walker
Nanostructured Lipid Carriers: A New Paradigm in Topical Delivery for Dermal and Transdermal Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 4
Gajanand Sharma, Bhupinder Singh, Kaisar Raza, Om Parkash Katare, Kanika Thakur
Oral Absorption Promoters: Opportunities, Issues, and Challenges
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 5
Sushilkumar Patil, Girish Kore, Atul Kolate, Chetan Yewale, Ambikanandan Misra
Recent Developments in the Use of Bioadhesive Systems for Delivery of Drugs to the Oral Cavity
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 4
John D. Smart