Выходит 6 номеров в год
ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Regulation of Cell Cycle Progression and Apoptosis by the Papillomavirus E6 Oncogene
Краткое описание
Infection with human papillomaviruses (HPV) is strongly associated with the development of cervical cancer. The HPV E6 gene is essential for the oncogenic potential of HPV. E6 abrogates multiple cell cycle checkpoints and modulates apoptosis. Loss of cell cycle checkpoints contributes to genomic instability, a hallmark of cancer cells. Cancer cells also show reduced propensity for apoptotic cell death. Inactivation of the tumor suppressor p53 by E6 is an important mechanism by which E6 promotes cell growth. The molecular basis for apoptosis modulation by E6 is poorly understood. Although it is expected that inactivation of p53 by E6 should lead to a reduction in cellular apoptosis, numerous studies showed that E6 could in fact sensitize cells to apoptosis. In this article, we present an overview of observations and current understanding of the molecular basis for E6-induced cell proliferation and apoptosis.
-
Zhang Weifang, Li Jing, Kanginakudru Sriramana, Zhao Weiming, Yu Xiuping, Chen Jason J., The human papillomavirus type 58 E7 oncoprotein modulates cell cycle regulatory proteins and abrogates cell cycle checkpoints, Virology, 397, 1, 2010. Crossref
-
Manzo-Merino Joaquin, Thomas Miranda, Fuentes-Gonzalez Alma M, Lizano Marcela, Banks Lawrence, HPV E6 oncoprotein as a potential therapeutic target in HPV related cancers, Expert Opinion on Therapeutic Targets, 17, 11, 2013. Crossref
-
Vande Pol Scott B., Klingelhutz Aloysius J., Papillomavirus E6 oncoproteins, Virology, 445, 1-2, 2013. Crossref
-
Zheng Qiaoli, Wang Tuan, Jiang Shaojie, Han Rui, Jin Na, Zhu Jiang, Zhou Qiang, Wang Hui, Chen Xianzhen, Cheng Hao, Meyers Craig, Production of Polyclonal Antibody to the HPV58 E7 Protein and Its Detection in Cervical Cancer, PLOS ONE, 11, 12, 2016. Crossref
-
Liu Yuxue, Yuan Xinxin, Wang Weixian, Wu Yuqing, Wu Lixin, High-affinity binding with specific peptides endows EuW10a good luminescence probe for HPV E6 detection, New Journal of Chemistry, 42, 21, 2018. Crossref
-
Tian Yonghao, Chen Hanxiang, Qiao Lijun, Zhang Wenhao, Zheng Jingyi, Zhao Weiming, Chen Jason. J., Zhang Weifang, CIP2A facilitates the G1/S cell cycle transition via B‐Myb in human papillomavirus 16 oncoprotein E6‐expressing cells, Journal of Cellular and Molecular Medicine, 22, 9, 2018. Crossref
-
Jia Xiang-Yu, Xue Ya-Rong, Zhang Chun-Xia, Luo Quan, Wu Yuqing, Highly sensitive detection of the human papillomavirus E6 protein by DNA-protected silver nanoclusters and the intrinsic mechanism, New Journal of Chemistry, 43, 37, 2019. Crossref
-
Kloth Judith N, Oosting Jan, van Wezel Tom, Szuhai Karoly, Knijnenburg Jeroen, Gorter Arko, Kenter Gemma G, Fleuren Gert Jan, Jordanova Ekaterina S, Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer, BMC Genomics, 8, 1, 2007. Crossref
-
Zhou Yunying, Pei Fengyan, Ji Mingyu, Zhang Fang, Sun Yingshuo, Zhao Qianqian, Wang Xiao, Hong Yatian, Tian Juanjuan, Wang Yunshan, Chen Jason J., WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5, BMC Cancer, 20, 1, 2020. Crossref
-
Heilman Susan A., Nordberg Joshua J., Liu Yingwang, Sluder Greenfield, Chen Jason J., Abrogation of the Postmitotic Checkpoint Contributes to Polyploidization in Human Papillomavirus E7-Expressing Cells, Journal of Virology, 83, 6, 2009. Crossref
-
Zhang Weifang, Liu Yingwang, Zhao Ning, Chen Hanxiang, Qiao Lijun, Zhao Weiming, Chen Jason J., Imperiale M. J., Role of Cdk1 in the p53-Independent Abrogation of the Postmitotic Checkpoint by Human Papillomavirus E6, Journal of Virology, 89, 5, 2015. Crossref
-
Liu Yingwang, Heilman Susan A., Illanes Diego, Sluder Greenfield, Chen Jason J., p53-Independent Abrogation of a Postmitotic Checkpoint Contributes to Human Papillomavirus E6-Induced Polyploidy, Cancer Research, 67, 6, 2007. Crossref
-
Park Jung Sun, Choi Hoon In, Kim Dong-Hyun, Kim Chang Seong, Bae Eun Hui, Ma Seong Kwon, Kim Soo Wan, Alpha-lipoic acid attenuates p-cresyl sulfate-induced renal tubular injury through suppression of apoptosis and autophagy in human proximal tubular epithelial cells, Biomedicine & Pharmacotherapy, 112, 2019. Crossref