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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Genetic Complexity of the Human Innate Host Defense Molecules, Surfactant Protein A1 (SP-A1) and SP-A2Impact on Function
Краткое описание
Innate immunity mechanisms play a critical role in the primary response to invading pathogenic microorganisms and other insulting agents. The innate lung immune system includes lung surfactant, a lipoprotein complex that carries out a function essential for life, that is, reduction of the surface tension at the air−liquid interphase of the alveolar space. By means of this function, pulmonary surfactant prevents lung collapse, therefore ensuring normal lung function and lung health. Pulmonary surfactant contains a number of host-defense molecules that are involved in the elimination of pathogens, viruses, particles, allergens, and other insults, as well as in the control of inflammation. This review is concerned with one of the surfactant proteins, the human (h) surfactant protein A (hSP-A), which, in addition to its role in surfactant-related functions, plays an important role in the modulation of lung host defense. The hSP-A locus has been identified with extensive complexity that may have an impact on its function, structure, and regulation. In humans, two genesSP-A1 (SFTPA1) and SP-A2 (SFTPA2)encode SP-A, with SP-A2 gene products being more biologically active than SP-A1 in most of the in vitro assays investigated. Although the two hSP-A genes share a high level of sequence similarity, differences in the structure and function between SP-A1 and SP-A2 have been observed in recent studies. In this review, we discuss the human SP-A complexity and how this may affect SP-A function.
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Jiang Xu, Fang Guodong, Dong Li, Jin Peifeng, Ding Lu, Zhang Haizeng, Fan Junming, Mao Sunzhong, Fan Xiaofang, Gong Yongsheng, Wang Yongyu, Chemical chaperone 4-phenylbutyric acid alleviates the aggregation of human familial pulmonary fibrosis-related mutant SP-A2 protein in part through effects on GRP78, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864, 10, 2018. Crossref
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Phelps David S., Chinchilli Vernon M., Weisz Judith, Yang Lili, Shearer Debra, Zhang Xuesheng, Floros Joanna, Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice, JCI Insight, 5, 24, 2020. Crossref
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Tekos Fotios, Skaperda Zoi, Goutzourelas Nikolaos, Phelps David S., Floros Joanna, Kouretas Demetrios, The Importance of Redox Status in the Frame of Lifestyle Approaches and the Genetics of the Lung Innate Immune Molecules, SP-A1 and SP-A2, on Differential Outcomes of COVID-19 Infection, Antioxidants, 9, 9, 2020. Crossref
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Gandhi Chintan K., Mikerov Anatoly N., Durrani Faryal, Umstead Todd M., Hu Sanmei, Wang Guirong, Phelps David S., Floros Joanna, Impact of Ozone, Sex, and Gonadal Hormones on Bronchoalveolar Lavage Characteristics and Survival in SP-A KO Mice Infected with Klebsiella pneumoniae, Microorganisms, 8, 9, 2020. Crossref
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Abbasi Ata, Chen Chixiang, Gandhi Chintan K., Wu Rongling, Pardo Annie, Selman Moises, Floros Joanna, Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis, Frontiers in Immunology, 13, 2022. Crossref
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Depicolzuane Lynnlee C., Roberts Catherine M., Thomas Neal J., Anderson-Fears Keenan, Liu Dajiang, Barbosa João Paulo Pereira, Souza Felipe Rodrigues, Pimentel André Silva, Floros Joanna, Gandhi Chintan K., Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children, Frontiers in Immunology, 13, 2022. Crossref
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Pastva Amy M., Walker Julia K. L., Maddox Lee A., Mukherjee Sambuddho, Giamberardino Charles, Hsia Bethany, Potts Erin, Zhu Hongmei, Degan Simone, Sunday Mary E., Lawson Barbara L., Korfhagen Thomas R., Schwartz David A., Eu Jerry P., Foster William M., McMahon Timothy J., Que Loretta, Wright Jo Rae, Nitric Oxide Mediates Relative Airway Hyporesponsiveness to Lipopolysaccharide in Surfactant Protein A–Deficient Mice, American Journal of Respiratory Cell and Molecular Biology, 44, 2, 2011. Crossref