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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
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François Jacob, Lysogeny, and the Development of the Operon Model
Краткое описание
This article summarizes the fundamental contribution of Francois Jacob in the field of molecular biology. Jacob was one of the handful of scientists who initiated the revolution in biology that took place in the second half of the 20th century. In their landmark publication of 1961, entitled "Genetic Regulatory Mechanisms in the Synthesis of Proteins", François Jacob and Jacques Monod presented a model for the regulation of gene expression deduced from genetic and biochemical studies. They proposed that a new class of genes, regulatory genes, would code for repressors that bind to operator sequences upstream of operons. The impact of the operon model was great: gene expression varies constantly and is under the direct control of proteins, two ideas that were revolutionary at the time they were proposed. It was also rapidly shown that in most organisms, except bacteria, co-regulated genes are not usually grouped together on the genome.
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Jacob F. The birth of the operon. Science. 2001; 332(6031):767.
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Lwoff A. Lysogeny. Bacteriol Rev. 1953;17(4):269-337.
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Beckwith J, Yaniv M. Francois Jacob (1920-2013). Curr Biol. 2013;23(10):R422-5.
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Petit C, Sansonetti P. Tribute to Francois Jacob (1920-2013). Le Lettre du Coll de France. 2015;9:1-10.
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Pardee AB, Jacob F, Monod J. The genetic control and cytoplasmic expression of inducibility in the synthesis of P-galactosidase by E. coli. J Mol Biol. 1959;1:165-78.
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Ullman A. Being around. In: Lwoff A, Ullman A, editors. Origins of molecular biology: A tribute to Jacques Monod. New York: Academic Press; 1979. p. 167.
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Jacob F. Genetic control of viral functions (1958). In: Jacob F, Peyrieras N, Morange M, editors. Travaux scientifiques de Francois Jacob. Paris: Odile Jacob; 2002.
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Gann A. Jacob and Monod: From operons to EvoDevo. Curr Biol. 2010;20:R718-23.
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Jacob F, Monod J. Genes de structure et genes de regulation dans la biosynthese des proteins. C R Hebd Seances Acad Sci. 1959;249:1282-4.
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Jacob F, Monod J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961;3:318-56.
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Gilbert W, Muller-Hill B. Isolation of the lac repressor. Proc Natl Acad Sci U S A. 1966;56(6):1891-8.
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Ptashne M. Isolation of the X phage repressor. Proc Natl Acad Sci U S A. 1967;57(2):306-13.
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Ullmann A. In memoriam: Jacques Monod (1910-1976). Genome Biol Evol. 2011;3:1025-33.