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Critical Reviews™ in Eukaryotic Gene Expression

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ISSN Печать: 1045-4403

ISSN Онлайн: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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François Jacob, Lysogeny, and the Development of the Operon Model

Том 30, Выпуск 5, 2020, pp. 443-446
DOI: 10.1615/CritRevEukaryotGeneExpr.2020035329
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Краткое описание

This article summarizes the fundamental contribution of Francois Jacob in the field of molecular biology. Jacob was one of the handful of scientists who initiated the revolution in biology that took place in the second half of the 20th century. In their landmark publication of 1961, entitled "Genetic Regulatory Mechanisms in the Synthesis of Proteins", François Jacob and Jacques Monod presented a model for the regulation of gene expression deduced from genetic and biochemical studies. They proposed that a new class of genes, regulatory genes, would code for repressors that bind to operator sequences upstream of operons. The impact of the operon model was great: gene expression varies constantly and is under the direct control of proteins, two ideas that were revolutionary at the time they were proposed. It was also rapidly shown that in most organisms, except bacteria, co-regulated genes are not usually grouped together on the genome.

Ключевые слова: biochemistry, history of science, gene, molecular biology
ЛИТЕРАТУРА
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  2. Lwoff A. Lysogeny. Bacteriol Rev. 1953;17(4):269-337.

  3. Beckwith J, Yaniv M. Francois Jacob (1920-2013). Curr Biol. 2013;23(10):R422-5.

  4. Petit C, Sansonetti P. Tribute to Francois Jacob (1920-2013). Le Lettre du Coll de France. 2015;9:1-10.

  5. Pardee AB, Jacob F, Monod J. The genetic control and cytoplasmic expression of inducibility in the synthesis of P-galactosidase by E. coli. J Mol Biol. 1959;1:165-78.

  6. Ullman A. Being around. In: Lwoff A, Ullman A, editors. Origins of molecular biology: A tribute to Jacques Monod. New York: Academic Press; 1979. p. 167.

  7. Jacob F. Genetic control of viral functions (1958). In: Jacob F, Peyrieras N, Morange M, editors. Travaux scientifiques de Francois Jacob. Paris: Odile Jacob; 2002.

  8. Gann A. Jacob and Monod: From operons to EvoDevo. Curr Biol. 2010;20:R718-23.

  9. Jacob F, Monod J. Genes de structure et genes de regulation dans la biosynthese des proteins. C R Hebd Seances Acad Sci. 1959;249:1282-4.

  10. Jacob F, Monod J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961;3:318-56.

  11. Gilbert W, Muller-Hill B. Isolation of the lac repressor. Proc Natl Acad Sci U S A. 1966;56(6):1891-8.

  12. Ptashne M. Isolation of the X phage repressor. Proc Natl Acad Sci U S A. 1967;57(2):306-13.

  13. Ullmann A. In memoriam: Jacques Monod (1910-1976). Genome Biol Evol. 2011;3:1025-33.

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