Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v8.i2.10
pages 107-123

Interleukins in the Control of Osteoclast Differentiation

T. John Martin
St. Vincent's Institute of Medical Research and University of Melbourne Department of Medicine, Fitzroy, 3065, Victoria, Australia
E. Romas
St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy 3065, Victoria, Australia
M. T. Gillespie
St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy 3065, Victoria, Australia

Краткое описание

To maintain homeostasis of bone, the production of osteoblasts and osteoclasts is tightly regulated. At the local level, hormones and cytokines control formation of osteoclasts from hemopoietic precursors by acting upon osteoblastic-stromal cells and in some cases also upon cells of the immune system. Osteoblasts regulate osteoclast formation by providing physical support and cytokines such as M-CSF and IL-11, which promote osteoclast differentiation. Osteoblasts are also a source of IL-18, which limits osteoclast formation. The requirement of contact between osteoblasts and hemopoietic cells for successful osteoclast formation led to a concept of a membrane-anchored stromal cell molecule that programs osteoclast differentiation. This mechanism has been highlighted by the discovery of osteoprotegerin (OPG), a soluble tumor necrosis factor (TNF) family member that inhibits osteoclast formation. The ligand for OPG is a novel transmembrane TNF receptor superfamily member, the osteoclast differentiating factor (ODF). The recognition of the osteoprotegerin/osteoprotegerin-ligand axis will lead to new insights into the control of osteoclast differentiation by interleukins.

Articles with similar content:

Immune Function of the Decoy Receptor Osteoprotegerin
Critical Reviews™ in Immunology, Vol.22, 2002, issue 3
Elizabeth J. Ryan, Asa K. Bengtsson
Action of RANKL and OPG for Osteoclastogenesis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 1
Yasuhiro Kobayashi, Nobuyuki Udagawa, Naoyuki Takahashi
Perspective. Osteoclastogenesis and Growth Plate Chondrocyte Differentiation: Emergence of Convergence
Critical Reviews™ in Eukaryotic Gene Expression, Vol.13, 2003, issue 2-4
Paul R. Odgren, William M. Philbrick, Alison Gartland
Properties of Glycolipid-Enriched Membrane Rafts in Antigen Presentation
Critical Reviews™ in Immunology, Vol.25, 2005, issue 1
William Rodgers, Kenneth Smith
Immunologic Nonresponsiveness to Tumors
Critical Reviews™ in Oncogenesis, Vol.9, 1998, issue 1
Martine Extermann, Scott J. Antonia, Richard A. Flavell