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Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v19.i4.30
pages 289-300

Gene Expression in Stem Cells

Yu Liang
Molecular Biology Systems Division, Life Technologies, Foster City, CA 94404
Iain Russell
Molecular Biology Systems Division, Life Technologies, Foster City, CA 94404
Criss Walworth
Molecular Biology Systems Division, Life Technologies, Foster City, CA 94404
Caifu Chen
Life Technologies
N/A

Краткое описание

Both embryonic and adult stem cells promise a precious cell source for the treatment of various degenerative diseases due to their capacity for self-renewal and ability to differentiate along multiple cell lineages. A lack of understanding surrounding the basic biology of stem cells, the stemness, continues to challenge successful clinical application of these cells. Gene expression analysis, both genome-wide and targeted at specific gene subsets, has played a key role in improving our understanding of the genetic attributes of stem cells through identification of molecular signatures that characterize normal stem cell function. Such approaches have facilitated the investigation of stemness in a subset of tumor cells, so-called cancer stem cells, and have started to unravel their roles in initiation and progression of tumors. This review summarizes recent advances of gene expression analysis in stem cell research and also discusses critical issues that remain to be elucidated in the search for cancer stem cells markers.


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