Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v14.i12.10
42 pages

Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML Factors

Jane B. Lian
Department of Biochemistry University of Vermont 89 Beaumont Ave., Given E210B Burlington, VT 05405
Amjad Javed
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655
Sayyed Kaleem Zaidi
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655
Christopher Lengner
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655
Martin Montecino
Centro de Investigaciones Biomedicas, Facultad de Ciencias Biologicas y Facultad de Medicina, Universidad Andres Bello, Santiago
Andre J. van Wijnen
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655
Janet L. Stein
Department of Biochemistry, University of Vermont 89 Beaumont Ave., Given E210E Burlington, VT 05405
Gary S. Stein
Department of Biochemistry University of Vermont 149 Beaumont Ave., HSRF 326 Burlington, VT 05405

Краткое описание

Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone in the adult involve an exquisite interplay of developmental cues, signaling proteins, transcription factors, and their coregulatory proteins that support differentiation of osteogenic lineage cells from the initial mesenchymal progenitor cell to the mature osteocyte in mineralized connective tissue. As regulatory factors continue to be identified, the complexity of the molecular mechanisms that control gene expression in osteoblast lineage cells and drive the osteoblast maturation process are being further appreciated. A central regulator of bone formation is the Runx2 (Cbfa1/AML3) transcription factor which fulfills its role as a master regulatory switch through unique properties for mediating the temporal activation and/or repression of cell growth and phenotypic genes as osteoblasts progress through stages of differentiation. This review examines the multifunctional roles of Runx2 during osteogenesis. Runx2 functions as a "platform protein" that interacts with a spectrum of coregulatory proteins to provide a combinatorial mechanism for integrating cell signaling pathways required for osteoblast differentiation and the tissue-specific regulation of gene expression. In a broader context, it has recently been appreciated that the Runx1 hematopoietic factor and the Runx3 gene associated with neural and gut development are also expressed in the skeleton, although at present our knowledge of their roles in bone formation is limited. Here we discuss the biological functions of Runx factors in promoting cell fate determination and lineage progression, which include (1) regulating gene activation and repression through coregulatory protein interactions and by supporting chromatin remodeling; (2) integrating ECM signaling and cues from developmental, hormonal, and signal transduction pathways by formation of complexes organized in subnuclear domains; and (3) mediating cell growth control. Last, a comprehensive understanding of Runx functions in the skeleton must consider the regulatory mechanisms that control Runx2 transcription and its functional activity through posttranslational modifications.


Articles with similar content:

Role of Runx Proteins in Chondrogenesis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Carolina A. Yoshida, Toshihisa Komori
Perspective. Osteoclastogenesis and Growth Plate Chondrocyte Differentiation: Emergence of Convergence
Critical Reviews™ in Eukaryotic Gene Expression, Vol.13, 2003, issue 2-4
Paul R. Odgren, William M. Philbrick, Alison Gartland
Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 1
Shuying Yang, Wei Chen, Carrie S. Soltanoff, Yi-Ping Li
Steel Factor and c-kit Protooncogene: Genetic Lessons in Signal Transduction
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 2-3
Janna M. Blechman, David Givol, Yosef Yarden, Sima Lev
Histone Deacetylase Co-Repressor Complex Control of Runx2 and Bone Formation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 3
Aswathy K. Nair, Eric D. Jensen, Jennifer J. Westendorf