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Critical Reviews™ in Eukaryotic Gene Expression

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ISSN Печать: 1045-4403

ISSN Онлайн: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Nuclear Receptor Regulation of Genes Involved in Bile Acid Metabolism

Том 12, Выпуск 2, 2002, 17 pages
DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i2.30
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Краткое описание

Over the past few decades, the nuclear receptor superfamily of transcription factors has provided many opportunities for therapeutic intervention in a variety of pathophysiological conditions. A major question now is how many additional drug targets can be identified within this class of proteins. Advances in differential gene expression (DGE) technologies allow powerful new approaches to answer this question. Although DGE analysis is but one of several modern approaches to target identification, it is especially pertinent for nuclear receptors because many of these proteins are ligand-regulated transcription factors that directly alter gene expression. This article will focus on recent DGE experiments that have elucidated the physiological role of nuclear receptors in regulation of the bile acid biosynthesis, transport, and metabolism in the liver. Of particular relevance is the role of nuclear receptors in regulating CYP7A1 because this gene encodes the enzyme controlling the first and rate-limiting step in cholesterol degradation to bile acids. Modulation of CYP7A1 expression could provide a therapeutic benefit for multiple disease conditions. This article will focus on the relative contributions of farnesoid X-activated receptor, liver receptor homologous protein-1, small heterodimer partner, pregnane X receptor, and liver X receptor to the regulation of this specific gene, and bile acid metabolism in general. These studies highlight the dynamic interplay between nuclear receptors in the regulation of specific metabolic pathways.

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