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Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.734 5-летний Импакт фактор: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015011074
pages 1-11

Cell Therapy in Duchenne Muscular Dystrophy Treatment: Clinical Trials Overview

Anna Bajek
Chair of Regenerative Medicine, Nicolaus Copernicus University, Bydgoszcz, Poland
Dorota Porowinska
Chair of Regenerative Medicine, Nicolaus Copernicus University, Bydgoszcz, Poland
Tomasz Kloskowski
Chair of Regenerative Medicine, Nicolaus Copernicus University, Bydgoszcz, Poland
Edyta Brzoska
Department of Cytology, Institute of Zoology, Faculty of Biology, University of Warsaw, Warsaw, Poland
Maria A. Ciemerych
Department of Cytology, Institute of Zoology, Faculty of Biology, University of Warsaw, Warsaw, Poland
Tomasz Drewa
Chair of Regenerative Medicine, Nicolaus Copernicus University, Bydgoszcz, Poland; Department of Urology, Nicolaus Copernicus Hospital, Torun, Poland

Краткое описание

Duchenne muscular dystrophy (DMD), the most common and most severe form of all muscular dystrophies, leads to progressive muscle fiber necrosis, fibroblast proliferation, and growth of fibrous tissue and fat. The most common cause of death in DMD patients is cardiac and respiratory failure. Current pharmacological and other treatment methods do not lead to full recovery. For this reason, new alternatives for skeletal muscle regeneration are being investigated. Transplantation of myoblasts from healthy donors is one studied approach to muscle treatment in DMD patients. However, the results of intramuscular injection of in vitro cultured myoblasts are still not satisfactory. The use of autologous stem cells is also proposed. Despite many ongoing studies, this therapy is still in preliminary testing and requires more experiments.