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Critical Reviews™ in Eukaryotic Gene Expression

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ISSN Печать: 1045-4403

ISSN Онлайн: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Epigenetic Modulation of Gene Expression in Mammalian Cells

Том 15, Выпуск 2, 2005, pp. 93-102
DOI: 10.1615/CritRevEukaryotGeneExpr.v15.i2.10
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Краткое описание

The precisely controlled regulation of gene expression plays an important role in normal cellular function, whereas abnormalities of gene expression can contribute to cancer and other diseases. Thus, the ability to selectively regulate gene expression is of tremendous importance, both as a basic research tool and as a potential therapeutic approach. Over the last two decades, several different strategies have been used for controlling expression of specific genes at the transcriptional and post-transcriptional levels. The best-known approach involves antisense oligonucleotides that downregulate gene expression through various mechanisms, most importantly by triggering the degradation of mRNA. The use of “esigned transcription factors”has also developed into an interesting technology since it allows either the enhancement or the reduction of expression of a targeted gene. Recently RNA interference has emerged as a powerful tool for selective inhibition of gene expression. This review examines the basic aspects, advantages, and liabilities of these three approaches to gene modulation.

ЦИТИРОВАНО В
  1. Alhaji Suleiman Yusuf, Ngai Siew Ching, Abdullah Syahril, Silencing of transgene expression in mammalian cells by DNA methylation and histone modifications in gene therapy perspective, Biotechnology and Genetic Engineering Reviews, 35, 1, 2019. Crossref

  2. Nguyen Khue Vu, Epigenetic Modulation of Human Neurobiological Disorders, in Epigenetics in Human Disease, 2018. Crossref

  3. Nguyen Khue Vu, Potential epigenomic co-management in rare diseases and epigenetic therapy, Nucleosides, Nucleotides & Nucleic Acids, 38, 10, 2019. Crossref

  4. Yu Ying, Yuan Jason X. -J., Approaches for Manipulation of Gene Expression, in Textbook of Pulmonary Vascular Disease, 2011. Crossref

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