Выходит 6 номеров в год
ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
The Role of Cathepsins in Osteoimmunology
Краткое описание
Cathepsins are proteases comprising two small groups of serine and aspartic cathepsins and a large group of lysosomal cysteine cathepsins. Most of them are ubiquitously expressed throughout human tissues but some of them display a more restricted expression pattern and are involved in explicit tasks such as collagen degradation in the process of bone and cartilage destruction or degradation of invariant chain peptides in the process of antigen processing and presentation. In addition to the aforementioned functions, cathepsins have been shown to play a critical role in the pathogenesis of osteoimmunological diseases involving mutual interactions between skeletal and immunological functions. The most convincing evidence that cathepsins participate in the pathogenesis of osteoimmunological disorders exists for cathepsins K and S. Therefore, this review focuses on recent advances in understanding the role of cathepsins K and S in osteoimmunology and highlights the progress that has been made in targeting cathepsins to treat diseases related to the skeletal or immune system.
-
Simmons Graham, Zmora Pawel, Gierer Stefanie, Heurich Adeline, Pöhlmann Stefan, Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research, Antiviral Research, 100, 3, 2013. Crossref
-
Rauner M., Föger-Samwald U., Kurz M.F., Brünner-Kubath C., Schamall D., Kapfenberger A., Varga P., Kudlacek S., Wutzl A., Höger H., Zysset P.K., Shi G.P., Hofbauer L.C., Sipos W., Pietschmann P., Cathepsin S controls adipocytic and osteoblastic differentiation, bone turnover, and bone microarchitecture, Bone, 64, 2014. Crossref
-
Pietschmann Peter, Cathepsin K inhibitors: emerging treatment options for osteoporosis, Wiener Medizinische Wochenschrift, 165, 3-4, 2015. Crossref
-
Buro Christin, Beckmann Svenja, Oliveira Katia C., Dissous Colette, Cailliau Katia, Marhöfer Richard J., Selzer Paul M., Verjovski-Almeida Sergio, Grevelding Christoph G., Jex Aaron R., Imatinib Treatment Causes Substantial Transcriptional Changes in Adult Schistosoma mansoni In Vitro Exhibiting Pleiotropic Effects, PLoS Neglected Tropical Diseases, 8, 6, 2014. Crossref
-
Verbovšek Urška, Motaln Helena, Rotter Ana, Atai Nadia A., Gruden Kristina, Van Noorden Cornelis J. F., Lah Tamara T., Harrison Jeffrey K., Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma, PLoS ONE, 9, 10, 2014. Crossref
-
Memmert S., Damanaki A., Nogueira A. V. B., Eick S., Nokhbehsaim M., Papadopoulou A. K., Till A., Rath B., Jepsen S., Götz W., Piperi C., Basdra E. K., Cirelli J. A., Jäger A., Deschner J., Role of Cathepsin S in Periodontal Inflammation and Infection, Mediators of Inflammation, 2017, 2017. Crossref
-
Han Yakun, Jin Ying, Miao Yibin, Shi Tie, Lin Xiaoping, Improved RANKL expression and osteoclastogenesis induction of CD27+CD38− memory B cells: A link between B cells and alveolar bone damage in periodontitis, Journal of Periodontal Research, 54, 1, 2019. Crossref
-
Yan Xu, Wu Zhou, Wang Biyao, Yu Tianhao, Hu Yue, Wang Sijian, Deng Chunfu, Zhao Baohong, Nakanishi Hiroshi, Zhang Xinwen, Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis, Evidence-Based Complementary and Alternative Medicine, 2020, 2020. Crossref
-
Esberg Anders, Isehed Catrine, Holmlund Anders, Lindquist Susanne, Lundberg Pernilla, Serum proteins associated with periodontitis relapse post‐surgery: A pilot study, Journal of Periodontology, 92, 12, 2021. Crossref