Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v17.i4.30
pages 281-293

Roles of Smad3 in TGF-β Signaling During Carcinogenesis

Caroline Millet
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 2056B, Bethesda, MD 20892-4256
Ying E. Zhang
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 2056B, Bethesda, MD 20892-4256

Краткое описание

Signaling of transforming growth factor β (TGF-β) is mediated through a heteromeric complex of two types of transmembrane receptors and downstream intracellular proteins known as Smads. Alterations of TGF-β signaling underlie various forms of human cancer and developmental diseases. Human genetic studies have revealed both point mutations and deletions of Smad2 or Smad4 in several types of cancers. However, the role of Smad3 in tumorigenesis is not clear. Recent data indicate that Smad3 also functions as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. In addition, Smad3 is essential for TGF-β-mediated immune suppression, and it plays an important role in regulating transcriptional responses that are favorable to metastasis. Therefore, through regulating different transcriptional responses, Smad3 functions as both a negative and positive regulator of carcinogenesis depending on cell type and clinical stage of the tumor.


Articles with similar content:

The Caspase-8 Modulator c-FLIP
Critical Reviews™ in Immunology, Vol.25, 2005, issue 1
Takao Kataoka
Yin Yang 1 in Human Cancer
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 3-4
Richard Byers, Khimara Naidoo, Sarah Nicholson, Helen Whitehouse
Chemoprevention of Colon Cancer by iNOS-Selective Inhibitors
Forum on Immunopathological Diseases and Therapeutics, Vol.3, 2012, issue 2
Chinthalapally V. Rao, Naveena B. Janakiram
Signal Transduction and Actin in the Regulation of G1-Phase Progression
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Maarten J. A. Moes, Johannes Boonstra
NPR-A: A Therapeutic Target in Inflammation and Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 1
Jia Zhang, Junhai Li, Yan Yan, Jiansheng Wang, Ya Yang, Jingkun Qu, Min Li