Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v17.i3.20
pages 187-196

Histone Deacetylase Co-Repressor Complex Control of Runx2 and Bone Formation

Eric D. Jensen
The Cancer Center, University of Minnesota, Minneapolis, MN 55455
Aswathy K. Nair
Graduate Program in Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455
Jennifer J. Westendorf
The Cancer Center, Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN 55455

Краткое описание

A decade has passed since the transcription factor, Runx2, was found to be essential for osteoblast development and chondrocyte hypertrophy. During the last 10 years, our understanding of Runx2's physiological roles and the molecular mechanisms whereby it regulates gene expression to control cell-cycle progression and cellular differentiation has increased exponentially. Runx2 is expressed in osteoblasts, prehypertrophic chondrocytes, mesenchymal cells of the perichondrium, T lymphocytes, endothelial cells, and breast and prostate epithelial cells, with increased expression observed in breast and prostate carcinomas. Although Runx2 and other mammalian Runt domain proteins were originally described as transcriptional activators, they are also transcriptional repressors and thus maintain functional similarities with their Drosophila homolog, Runt. Runx2 binds a consensus DNA sequence but does not possess any enzymatic activities that directly affect chromatin structure. It alters gene expression by recruiting cofactors to gene regulatory elements. Histone deacetylases (HDACs) are among the co-repressors that interact with Runx2. In this review, we summarize data demonstrating that several HDACs and their associated proteins interact with Runx2, regulate its activity, and affect bone formation. HDACs are components of multiprotein complexes that interact with many transcription factors and are subject to regulation by extracellular signals. The elucidation of HDAC complex components that influence Runx2 activity in specific cell types and in response to various extracellular stimuli will increase our understanding of how this crucial transcription factor functions, and how we might be able to control its activity to influence bone formation or reduce bone disease associated with cancer metastasis.

Articles with similar content:

Oncogene-lnitiated Aberrant Signaling Engenders the Metastatic Phenotype: Synergistic Transcription Factor Interactions are Targets for Cancer Therapy
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 3-4
David T. Denhardt
Regulatory Controls for Osteoblast Growth and Differentiation: Role of Runx/Cbfa/AML Factors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 1&2
Sayyed Kaleem Zaidi, Janet L. Stein, Jane B. Lian, Martin Montecino, Andre J. van Wijnen, Amjad Javed, Gary S. Stein, Christopher Lengner
Contributions of the Histone Arginine Methyltransferase PRMT6 to the Epigenetic Function of RUNX1
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 3
Joern Lausen
Structure-Function Studies of ETS Transcription Factors
Critical Reviews™ in Oncogenesis, Vol.11, 2000, issue 3&4
Murielle Mimeault
MicroRNA Regulation of T-Lymphocyte Immunity: Modulation of Molecular Networks Responsible for T-Cell Activation, Differentiation, and Development
Critical Reviews™ in Immunology, Vol.33, 2013, issue 5
Daniel R. Salomon, Katie Podshivalova