Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2016016307
pages 163-171

Events of Molecular Changes in Epithelial-Mesenchymal Transition

Srishti Kotiyal
Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, Uttar Pradesh, India
Susinjan Bhattacharya
Department of Biotechnology, Jaypee Institute of Information Technology

Краткое описание

EMT is the process by which epithelial cells, characterized by well-developed intercellular contacts, transdifferentiate into motile and invasive mesenchymal cells. This process is associated with the loss of transmembrane intercellular adhesion molecule E-cadherin and disruption of cell-cell junctions along with acquisition of migratory properties. EMT is integral in embryonic development, wound healing, and stem cell behavior; however, its aberrant activation by micro-environmental alterations and abnormal stimuli can lead to cancer progression. Here, we review the different molecular changes associated with EMT that are responsible for downregulation of epithelial genes. Increased knowledge of the EMT process is essential for therapeutic targeting of cancer cells.

Ключевые слова: Cell junctions, Cytoskeletal changes, EMT, GTPase, miRNA

Articles with similar content:

Cell Signaling Pathways Related to Epithelial Mesenchymal Transition in Cancer Metastasis
Critical Reviews™ in Oncogenesis, Vol.24, 2019, issue 1
Sevinc Inan, Mürvet Hayran
Downregulation of Gap Junctions in Cancer Cells
Critical Reviews™ in Oncogenesis, Vol.12, 2006, issue 3-4
Yasufumi Omori, Edward Leithe, Edgar Rivedal, Solveig Sirnes
Regulation of RUNX1 Transcriptional Function by GATA-1
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 4
Kamaleldin E. Elagib, Adam N. Goldfarb
Tissue-Specific Transformation by Oncogenic Mutants of Epidermal Growth Factor Receptor
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 4
H. J. Kung, T. H. Carter
Tumor Suppressor Maspin as a Rheostat in HDAC Regulation to Achieve the Fine-Tuning of Epithelial Homeostasis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 3
M. Margarida Bernardo, Shijie Sheng, Sijana Dzinic, Alexander Kaplun