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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Biocompatible Nanometal Particle Fluorescence Enhancers
Краткое описание
Fluorometry has been used for more than a century to enhance the understanding of phenomena in molecular biology. With recent advances in light detection techniques, it is even more actively used in research now. The effectiveness of fluorometry highly depends on the intensity of the fluorescence from the target molecules in contrast to the background. Instrumentation for amplifying fluorescence signals may not selectively enhance signals only from the target. Therefore, a method to retrieve more fluorescence emission from a fluorophore is beneficial. Nanometal particles have high-density surface plasmon polariton fields, and when a fluorophore is placed within these fields, the electrons involved in the fluorescence emission may be altered in their energy states. The level of alteration depends upon the metal type, size of the particle, quantum yield of a fluorophore, and, most importantly, the distance between the nanoparticle and the fluorophore. Some organic solvents are also found to enhance fluorescence, possibly by the dipole-dipole coupling between the fluorophore and the solvent, resulting in an increase in the energy gap between the excited and the ground states. In this article, study results of the application of nanometal particles and biocompatible solvents for increasing the sensitivity/resolution in fluorophore-mediated biosensing/bioimaging are reviewed.
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Gary Ramla, Amelio Daniela, Garofalo Filippo, Petriashvili Gia, De Santo Maria Penelope, Ip Yuen Kwong, Barberi Riccardo, Endothelial-like nitric oxide synthase immunolocalization by using gold nanoparticles and dyes, Biomedical Optics Express, 6, 12, 2015. Crossref
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Wang Jianting, Achilefu Samuel, Nantz Michael, Kang Kyung A., Gold nanoparticle–fluorophore complex for conditionally fluorescing signal mediator, Analytica Chimica Acta, 695, 1-2, 2011. Crossref
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Gary Ramla, Carbone Giovani, Petriashvili Gia, De Santo Maria, Barberi Riccardo, Detection of Gold Nanoparticles Aggregation Growth Induced by Nucleic Acid through Laser Scanning Confocal Microscopy, Sensors, 16, 2, 2016. Crossref
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Tang Liang, Ren Yongjie, Hong Bin, Kang Kyung A., Fluorophore-mediated, fiber-optic, multi-analyte, immunosensing system for rapid diagnosis and prognosis of cardiovascular diseases, Journal of Biomedical Optics, 11, 2, 2006. Crossref
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Kang Kyung A., Mapping PVS by Molecular Imaging with Contrast Agents, in The Primo Vascular System, 2012. Crossref
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Kang Kyung A., Wang Jianting, O’Toole Martin G., Nantz Michael, Moore Joseph D., Laulhe Sebastien, Achilefu Samuel, Sensitivity Enhancement of NIR Fluorescence Contrast Agent Utilizing Gold Nanoparticles, in Oxygen Transport to Tissue XXXIII, 737, 2012. Crossref
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Kang Kyung A., Hong Bin, Jin Hanzhu, Nano Metal Particles for Biomedical Applications, in NanoScience in Biomedicine, 2009. Crossref
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Wang Jianting, Honga Bin, Kaib Junhai, Hanb Jungyoup, Zoub Zhiwei, Ahnb Chong H., Kanga Kyung A., Mini Sensing Chip for Point-of-Care Acute Myocardial Infarction Diagnosis Utilizing Micro-Electro-Mechanical System and Nano-Technology, in Oxygen Transport to Tissue XXX, 645, 2009. Crossref
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Hong Bin, Tang Liang, Ren Yongjie, Kang Kyung A., Real-Time, Automated, Fluorophore Mediated Multi-Cardiac Marker Biosensing System with Nano-Metallic Particle Reagent, in Oxygen Transport to Tissue XXVIII, 599, 2007. Crossref
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Wang Jianting, Nantz Michael H., Achilefu Samuel, Kang Kyung A., FRET-Like Fluorophore-Nanoparticle Complex for Highly Specific Cancer Localization, in Oxygen Transport to Tissue XXXI, 662, 2010. Crossref
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Hong Bin, Kai Junhai, Ren Yongjie, Han Jungyoup, Zou Zhiwei, Ahn Chong H., Kang Kyung A., Highly Sensitive Rapid, Reliable, and Automatic Cardiovascular Disease Diagnosis with Nanoparticle Fluorescence Enhancer and Mems, in Oxygen Transport to Tissue XXIX, 614, 2008. Crossref
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