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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Silencing or Knocking Out Eukaryotic Gene Expression by Oligodeoxynucleotide Decoys
Краткое описание
The elucidation of molecular and signaling pathways in eukaryotic cells is often achieved by targeting regulatory element(s) found in the promoter or the enhancer region of eukaryotic gene(s) using a double-stranded (ds) oligodeoxynucleotide (ODN) containing a specific cis-element. Our laboratory is focusing on dsODN decoys containing the TGF-β element as a novel nonsteroidal antifibrotic for achieving normal wound healing. In the model systems discussed, there is either a specific gene possessing a specific cis-element or a cluster of genes with one gene containing the consensus cis-element. The rest of the genes in the cluster contain the cis-elements homologous to this consensus element, which allows for dsODN decoy regulation of a gene cluster at one time.
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Goodarzi Hani, Elemento Olivier, Tavazoie Saeed, Revealing Global Regulatory Perturbations across Human Cancers, Molecular Cell, 36, 5, 2009. Crossref
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Cutroneo Kenneth R., White Sheryl L., Phan Sem H., Ehrlich H. Paul, Therapies for bleomycin induced lung fibrosis through regulation of TGF-β1 induced collagen gene expression, Journal of Cellular Physiology, 211, 3, 2007. Crossref
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Lok Chun-Nam, Ehrlich H. Paul, White Sheryl L., Buttolph Thomas R., Cutroneo Kenneth R., Chiu Jen-Fu, Oligodeoxynucleotide decoy therapy blocks type 1 procollagen transcription and the prolyl hydroxylase β subunit translation, Journal of Cellular Biochemistry, 103, 4, 2008. Crossref
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Adach-Kilon Alicja, Swiatek-Machado Karolina, Kaminska Bozena, Dabrowski Michal, Signal transducer and activator of transcription 1 (Stat1) maintains basal mRNA expression of pro-survival stat3-target genes in glioma C6 cells, Journal of Cellular Biochemistry, 112, 12, 2011. Crossref
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Goodarzi Hani, Najafabadi Hamed S., Oikonomou Panos, Greco Todd M., Fish Lisa, Salavati Reza, Cristea Ileana M., Tavazoie Saeed, Systematic discovery of structural elements governing stability of mammalian messenger RNAs, Nature, 485, 7397, 2012. Crossref
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Cao Shouqiang, Wang Chao, Zheng Qian, Qiao Ying, Xu Ke, Jiang Tao, Wu Anhua, STAT5 regulates glioma cell invasion by pathways dependent and independent of STAT5 DNA binding, Neuroscience Letters, 487, 2, 2011. Crossref
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Sinha Saurabh, Adler Adam S., Field Yair, Chang Howard Y., Segal Eran, Systematic functional characterization of cis-regulatory motifs in human core promoters , Genome Research, 18, 3, 2008. Crossref
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Goodarzi Hani, Zhang Steven, Buss Colin G., Fish Lisa, Tavazoie Saeed, Tavazoie Sohail F., Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins, Nature, 513, 7517, 2014. Crossref