Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v8.i1.40
pages 81-106

Regulatory Parameters of DNA Replication

Maria Zannis-Hadjopoulos
McGill Cancer Centre, McGill University, 3655 Drummond Street, Montreal, Quebec H3G 1Y6, CANADA
Gerald B. Price
McGill Cancer Centre, McGill University, 3655 Drummond Street, Montreal, Quebec H3G 1Y6, CANADA

Краткое описание

One of the fundamental characteristics that help define life is the ability to propagate. At the basest level in the act of propagation is replication of the genetic information as the databank and architectural plans for each particular life form. Thus propagation of life requires the replication of the genome−for the purposes of our review, eukaryotic DNA replication. In this critical review, we have chosen to present the issues and supporting experimental evidence in question-and-answer format. Over the past 3 to 4 years, the research domain of eukaryotic DNA replication has developed a new dynamism. This new force in discovery of the fundamental elements and mechanisms for DNA replication in higher eukaryotes has been propelled by accepted methodologies for mapping (identification) of origins of DNA replication, applicable to mammalian DNA replication, and by the discovery of the origin recognition complex (ORC) in yeast, which has served as a model in the search for the mammalian equivalent.

Ключевые слова: regulation, DNA replication, eukaryotes, origins.

Articles with similar content:

Parameters of Quantitative Trait Loci
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 4
Weikuan Gu, Jian Yan
The Ability to Transfer in Individuals with Spinal Cord Injury
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.9, 1997, issue 2
G. T. Allison
A Close Examination of Genes within Quantitative Trait Loci of Bone Mineral Density in Whole Mouse Genome
Critical Reviews™ in Eukaryotic Gene Expression, Vol.18, 2008, issue 4
Weikuan Gu, Caili Han, Wesley G. Beamer, Qing Xiong
The Complexity in Hunting for Candidate Genes Within QTL That Determine Susceptibility to Arthritis in Rats
Critical Reviews™ in Immunology, Vol.28, 2008, issue 2
Weikuan Gu, S. Terry Canale, Jiaqian Zhu, Karen A. Hasty, Qing Xiong, John M. Stuart
Development and Application of Tissue Microarrays for Biomarker Studies
Forum on Immunopathological Diseases and Therapeutics, Vol.2, 2011, issue 2
Linda Shevlin, Lee Goodglick, Maoyong Fu, Yahya Elshimali, Samson Schatz, David Chia, Ai Li, Madhuri Wadehra, Steve Horvath, Nam K. Yoon, George Chang, Erin Maresh, Lily Zhang, Mohammad Alavi, Angela Presson, Lora Bagryanova, Longsheng Hong, Vei H. Mah