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Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i4.10
22 pages

Estrogen Receptor Action

Stefan Nilsson
Karo Bio AB, Novum, SE-141 57 Huddinge, Sweden
Jan-Ake Gustafsson
Department of Medical Nutrition, Novum, SE-14186 Huddinge, Sweden

Краткое описание

Today we have to consider the existence of two estrogen receptors, a and b, in our attempts to understand the role of estrogen receptors in physiology and pathology, and to explain the pharmacology of estrogens, antiestrogens, and SERMs. Both ERa and ERb belong to the large family of nuclear receptors that function as hormone-dependent transcription factors with important roles in the endocrine signaling system. Estrogen signaling is dependent on multiple mechanisms involving the two estrogen receptors and, perhaps, also other, non–estrogen receptor–related proteins. In the post-genomic era, with the help of technological advancements, we will see a dramatic increase in our understanding of the biological role of the two estrogen receptors, and in the function of estrogens, antiestrogens, and SERMs, which will significantly enhance our chances to develop designer drugs with dramatically improved therapeutic profiles.

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