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Critical Reviews™ in Eukaryotic Gene Expression

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ISSN Печать: 1045-4403

ISSN Онлайн: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Paracrine Sonic Hedgehog Signaling Derived from Tumor Epithelial Cells: A Key Regulator in the Pancreatic Tumor Microenvironment

Том 22, Выпуск 2, 2012, pp. 97-108
DOI: 10.1615/CritRevEukarGeneExpr.v22.i2.20
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Краткое описание

Activation of the hedgehog (Hh) signaling pathway is involved in embryo development and tumorigenesis. While normal pancreatic tissue exhibits little Hh pathway activity, patients with pancreatic adenocarcinoma have high levels of Hh pathway signaling in both the tumor epithelia and the surrounding stromal tissue. Hh ligands expressed by pancreatic cancers promote tumor growth indirectly by activating Hh signaling in the surrounding stroma. This paracrine activation of Hh signaling in the tumor microenvironment provides a more favorable environment for tumor cellular proliferation, metastasis, and resistance to therapy. Taken together, these findings are of valuable implications for the use of Hh pathway inhibitors currently in development and inhibition of the Hh pathway paracrine loop in pancreatic cancer.

ЦИТИРОВАНО В
  1. Merchant Juanita L., Saqui-Salces Milena, Inhibition of Hedgehog signaling in the gastrointestinal tract: Targeting the cancer microenvironment, Cancer Treatment Reviews, 40, 1, 2014. Crossref

  2. Lei Jianjun, Fan Lin, Wei Guangbing, Chen Xin, Duan Wanxing, Xu Qinhong, Sheng Wei, Wang Kang, Li Xuqi, Gli-1 is crucial for hypoxia-induced epithelial-mesenchymal transition and invasion of breast cancer, Tumor Biology, 36, 4, 2015. Crossref

  3. Chitkara Deepak, Mittal Anupama, Mahato Ram I., miRNAs in pancreatic cancer: Therapeutic potential, delivery challenges and strategies, Advanced Drug Delivery Reviews, 81, 2015. Crossref

  4. Cai Heng, Li Hongxing, Li Jingmin, Li Xiaoyan, Li Yana, Shi Yan, Wang Dong, Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma, Tumor Biology, 37, 12, 2016. Crossref

  5. Lin Huey-Jen, Lin Jiayuh, Seed-in-Soil: Pancreatic Cancer Influenced by Tumor Microenvironment, Cancers, 9, 12, 2017. Crossref

  6. Agrawal Vijayendra, Kim Dong Young, Kwon Young-Guen, Hhip regulates tumor-stroma-mediated upregulation of tumor angiogenesis, Experimental & Molecular Medicine, 49, 1, 2017. Crossref

  7. ZHANG YONGJIAN, LIU WEI, HE WENBO, ZHANG YUANYUAN, DENG XIULING, MA YANMIN, ZENG JIN, KOU BO, Tetrandrine reverses epithelial-mesenchymal transition in bladder cancer by downregulating Gli-1, International Journal of Oncology, 48, 5, 2016. Crossref

  8. Vuaroqueaux Vincent, Peille Anne-Lise, Zeitouni Bruno, Eades-Perner Anne-Marie, Fiebig Heinz-Herbert, Molecular Characteristics of Patient-Derived Tumor Xenografts: Similarities to Patient Tumors and Relevance for Biomarker Discovery, in Patient-Derived Mouse Models of Cancer, 2017. Crossref

  9. Réda Jiri, Vachtenheim Jiri, Vlčková Kateřina, Horák Pavel, Vachtenheim Jiri, Ondrušová Lubica, Widespread Expression of Hedgehog Pathway Components in a Large Panel of Human Tumor Cells and Inhibition of Tumor Growth by GANT61: Implications for Cancer Therapy, International Journal of Molecular Sciences, 19, 9, 2018. Crossref

  10. Qian Weikun, Li Jie, Chen Ke, Jiang Zhengdong, Cheng Liang, Zhou Cancan, Yan Bin, Cao Junyu, Ma Qingyong, Duan Wanxing, Metformin suppresses tumor angiogenesis and enhances the chemosensitivity of gemcitabine in a genetically engineered mouse model of pancreatic cancer, Life Sciences, 208, 2018. Crossref

  11. Upadhrasta Sireesha, Zheng Lei, Strategies in Developing Immunotherapy for Pancreatic Cancer: Recognizing and Correcting Multiple Immune “Defects” in the Tumor Microenvironment, Journal of Clinical Medicine, 8, 9, 2019. Crossref

  12. Liu Zhengsheng, Zhang Ling, Tian Zhou, Kong Chao, Liu Chun, Liu Huiqin, Yuan Fang, Kong Weijian, Qian Feng, Paclitaxel and Itraconazole Co‐Encapsulated Micelle Prolongs the Survival of Spontaneous LSL‐KrasG12D/+, LSL‐Trp53R172H/+, Pdx‐1‐Cre Genetically Engineered Mouse Model of Pancreatic Cancer, Advanced Therapeutics, 2, 9, 2019. Crossref

  13. Saini Francesca, Argent Richard H., Grabowska Anna M., Sonic Hedgehog Ligand: A Role in Formation of a Mesenchymal Niche in Human Pancreatic Ductal Adenocarcinoma, Cells, 8, 5, 2019. Crossref

  14. Jeng Kuo-Shyang, Chang Chiung-Fang, Lin Shu-Sheng, Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments, International Journal of Molecular Sciences, 21, 3, 2020. Crossref

  15. Bhat Anjali, Sharma Aman, Bharti Alok Chandra, Upstream Hedgehog signaling components are exported in exosomes of cervical cancer cell lines, Nanomedicine, 13, 17, 2018. Crossref

  16. Li Xuqi, Wang Zheng, Ma Qingyong, Xu Qinhong, Liu Han, Duan Wanxing, Lei Jianjun, Ma Jiguang, Wang Xiu, Lv Shifang, Han Liang, Li Wei, Guo Jian, Guo Kun, Zhang Dong, Wu Erxi, Xie Keping, Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer, Clinical Cancer Research, 20, 16, 2014. Crossref

  17. Rucki Agnieszka A., Xiao Qian, Muth Stephen, Chen Jianlin, Che Xu, Kleponis Jennifer, Sharma Rajni, Anders Robert A., Jaffee Elizabeth M., Zheng Lei, Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment, Molecular Cancer Therapeutics, 16, 11, 2017. Crossref

  18. Kiseleva Anna A., Korobeynikov Vladislav A., Nikonova Anna S., Zhang Peishan, Makhov Petr, Deneka Alexander Y., Einarson Margret B., Serebriiskii Ilya G., Liu Hanqing, Peterson Jeffrey R., Golemis Erica A., Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs, Clinical Cancer Research, 25, 13, 2019. Crossref

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