Доступ предоставлен для: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Выходит 6 номеров в год

ISSN Печать: 1045-4403

ISSN Онлайн: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Expression of Pluripotency Markers, SOX2 and OCT4, in Pterygium Development

Том 28, Выпуск 2, 2018, pp. 155-162
DOI: 10.1615/CritRevEukaryotGeneExpr.2018024658
Get accessGet access

Краткое описание

Pterygium is a common ocular surface disease characterized by the abnormal epithelial proliferation, matrix remodeling, vascularization and the migration of the lesion. Although the etiology of pterygium is elusive, recent studies have focused on the role of limbal stem cells (LSCs) damage and effects of UVB. This study aimed to determine the expression levels of pluripotent markers of SOX2 and OCT4 in primary pterygium and normal conjunctiva.
Using real time polymerase chain reaction (PCR), the SOX2 and OCT4 expressions were compared in primary pterygium and normal conjunctiva. This study assessed the correlation between SOX2 mRNA expression and OCT4 mRNA expression, as well as the association between the clinicopathological indices and both gene expression levels. The relative mRNA expression levels of OCT4 genes in primary pterygium were significantly reduced compared to the normal conjunctiva tissues. The association between OCT4 gene expression and the clinicopathological indices reported significant laterality (P = .004) and marginal growth activity indices (P = .063). The univariate correlation between the SOX2 and OCT4 expressions was statistically significant (P = .001).
The present study emphasized the downregulation of pluripotent marker OCT4 genes in the pterygium. It is speculated that these results may predict a new avenue for exploring the role of stem cell deficiency in the development of pterygium.

Ключевые слова: pluripotency markers, mRNA expression, SOX2, OCT4, pterygium
ЦИТИРОВАНО В
  1. Meshkani Seyed Elyas, Kooshan Narges, Moghadam Arezoo Baradaran, Falanji Farahnaz, Adli Abolfazl, Baghbani‐Arani Fahimeh, Arian Alireza Ghasemi, Rad Abolfazl, Signaling roadmap to epithelial–mesenchymal transition in pterygium, TWIST1 centralized , Journal of Cellular Physiology, 234, 10, 2019. Crossref

1286 Просмотры статей 37 Загрузка статей Метрики
1286 ПРОСМОТРЫ 37 ЗАГРУЗКИ 1 Crossref ЦИТАТЫ Google
Scholar
ЦИТАТЫ

Статьи с похожим содержанием:

UTP23 Is a Promising Prognostic Biomarker and Is Associated with Immune Infiltration in Breast Cancer Critical Reviews™ in Eukaryotic Gene Expression, Vol.34, 2024, issue 3
Jun Wang, Weiping He, Jindong Li, Li Yang, Siman Xie, Yan Zhang, Benteng Zhang
Effects of RNA Modification "Writers" of GALNT2 on the Tumor Microenvironment in Cervical Squamous Cell Carcinoma Journal of Environmental Pathology, Toxicology and Oncology, Vol.41, 2022, issue 4
Lin Chen, Shizhang Wang
Oncogenic Long Noncoding RNA Linc01287 Promotes IGF1R Expression by Sponging miR-98 in Breast Cancer Critical Reviews™ in Eukaryotic Gene Expression, Vol.32, 2022, issue 3
Louming Guo , Chenxu Guo , Mingliang Zhang, Jun Qian , Pengcheng Li
Chemotherapeutic Drugs Endow Gastric Cancer Mesenchymal Stem Cells with Stronger Tumor-Promoting Ability Journal of Environmental Pathology, Toxicology and Oncology, Vol.43, 2024, issue 1
Bo Shen, Chao Huang, Miaolin Zhu, Wei Zhu, Jiaqi Shen, Mei Wang, Zhihong Chen, Linjing Cui, Yuanyuan Zhao
hsa_circ_0051428 Facilitates the Progression of Thyroid Cancer by Sponging miR-1248 to Up-Regulate FN1 Critical Reviews™ in Eukaryotic Gene Expression, Vol.33, 2023, issue 4
Yiqing Tan, Fuhua Wang, Yuanyuan Zhang, Tao Zhou, Shengpan Jiang, Lili Xu, Wenfeng Lei, Shilin Zheng

Статьи, принятые к публикации

PRMT6 promotes the immune evasion of gastric cancer via upregulating ANXA1 Liang Xu, Fenger Zhang, Binqi Yu, Shengnan Jia, Sunfu Fan PURPL promotes M2 macrophage polarization in lung cancer via regulating RBM4/xCT signaling Jipeng Guo, Chongwen Gong, Hao Wang SIAH1 promotes the pyroptosis of cardiomyocytes in diabetic cardiomyopathy via regulating IκB-α/NF-κB signaling Jinbin Wu, Yaoming Yan SLC7A2-mediated lysine catabolism inhibits immunosuppression in triple negative breast cancer Yuanyuan Sun, Yaqing Li, Chengying Jiang, Chenying Liu, Yuanming Song SIAH2-mediated degradation of ACSL4 inhibits the anti-tumor activity of CD8+ T cells in hepatocellular carcinoma Fangzheng Shu, Yuhua Shi, Xiangxiang Shan, Wenzhang Zha, Rengen Fan, Wanjiang Xue RBM15-mediated N6-methyl adenosine (m6A) modification of EZH2 drives the epithelial-mesenchymal transition of cervical cancer Ruixue Wang, Wenhua Tan Evidence-Based Storytelling and A Strategic Roadmap to Promote Cancer Prevention Via Adolescent HPV Vaccination in Northern New England Matthew Dugan, Gary Stein, Jan Carney, Sheila Clifford-Bova KDM4A-AS1 promotes cell proliferation, migration and invasion via the miR-4306/STX6 axis in hepatocellular carcinoma Wei Cao, Yuhan Ren, Ying Liu, Guoshu Cao, Zhen Chen, Fan Wang HDAC1-mediated downregulation of NEU1 exacerbates the aggressiveness of cervical cancer Nanzi Xie, Sisi Mei, Changlan Dai, Wei Chen Effect of miR-26b-5p on progression of acute myeloid leukemia by regulating USP48-mediated Wnt/β-catenin pathway Yu Xie, Lin Tan, Kun Wu, Deyun Li, Chengping Li
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain