Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i1.90
pages 83-96

Contribution of Neural Stem Cells to Regeneration of the Central Nervous System

Oksana A. Rybachuk
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana A. Pivneva
Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv; State Key Laboratory of Molecular and Cellular Biology, Bogomolets Institute of Physiology, Kyiv, Ukraine

Краткое описание

The central nervous system (CNS) of adult mammals, including humans, serves a typical example of organs that are not restored. However, currently, innovative treatment options aimed at regenerating of damaged CNS tissues have been attracting the growing interest. These options are based on the latest achievements in the field of stem cells and neurology. The recapitulation of normal neural development has become a vital strategy for CNS regeneration. Normal development of the CNS is triggered by induction of the stem cells in it, in other words, neural stem cells (NSCs). Thus, introduction or mobilization of NSCs could be expected to regenerate the CNS through both activation of endogenous regenerative capacity and transplantation of NSCs. This review elucidates recent data on the progress in basic stem cell biology, as well as the mechanisms of NSCs' ontogenic changes, the prospective of identification, potential differentiation, and their therapeutic applications have been elucidated.


Articles with similar content:

Strategies for Regeneration of Heart Muscle
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 1
Glenn R. Gaudette, Ira S. Cohen, Jacques P. Guyette
Migration and Differentiation of Fetal Neural Progenitor Cells in the Brain of Ischemic Animals
International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 1
A. O. Poddubna, O. M. Tsupykov, Tetyana A. Pivneva, Gennadi M. Butenko, Vitaliy Kyryk, O. V. Kuchuk, Galina G. Skibo
Ciliary Epithelium: An Underevaluated Target for Therapeutic Regeneration
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 2
Akshay Anand, Chandrika Abburi
Immune-Derived Cytokines in the Nervous System: Epigenetic Instructive Signals or Neuropathogenic Mediators?
Critical Reviews™ in Immunology, Vol.19, 1999, issue 2
Valeria Fiorelli, Maria De Cristofaro, Laura Vincenzi, Simone Topino, Maria Caterina Sirianni, Arianna Novi, Giuseppe Luzi, Fabrizio Ensoli, Donatella Santini Muratori
Biomechanics of Single Chondrocytes and Osteoarthritis
Critical Reviews™ in Biomedical Engineering, Vol.30, 2002, issue 4-6
Kyriacos A. Athanasiou, Adrian C. Shieh