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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i3.60
pages 245-251

Increased Sensitivity of Mitochondrial Permeability Transition Pore to Ca2+ in the Heart of Spontaneously Hypertensive Rats

Nataliya A. Strutynska
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Nataliya A. Dorofeyeva
Bogomolets Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, Ukraine
Galyna L. Vavilova
Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv
Vadim F. Sagach
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Краткое описание

In vitro experiments on the mitochondria isolated from adult normotensive and spontaneously hypertensive rat hearts, an increased sensitivity of mitochondrial permeability transition pore (mPTP) to Ca2+, its natural inducer, has been revealed. In spontaneously hypertensive rats, it is evoked by the reduction of active ion concentration by two orders, which causes organelle swelling. Calcium-induced swelling of the mitochondria isolated from the normotensive rats (control) is completely prevented by cyclosporin A (10−5 mol/l), a natural mPTP inhibitor, while in spontaneously hypertensive rats, it is prevented only partially (by 54%), indicating the presence of cyclosporin A-insensitive mPTP component. The results obtained give reason to conclude that hypertension is associated with mitochondrial dysfunction, characterized, in particular, by increased mPTP sensitivity to Ca2+, which may elicit widespread tissue damage, accompanying diseases of the cardiovascular system, especially hypertension.


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